Protein-tyrosine phosphatases and cancer

被引：550

作者：

Östman, A

Hellberg, C

Böhmer, FD

机构：

[1] Univ Jena, Inst Mol Cell Biol, Fac Med, D-07747 Jena, Germany

[2] Karolinska Inst, Canc Ctr Karolinska, Dept Pathol & Oncol, Stockholm, Sweden

[3] Ludwig Inst Canc Res, Uppsala Branch, S-75124 Uppsala, Sweden

[4] Univ Jena, Inst Mol Cell Biol, Fac Med, D-07747 Jena, Germany

来源：

NATURE REVIEWS CANCER | 2006年 / 6卷 / 04期

关键词：

D O I：

10.1038/nrc1837

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Tyrosine phosphorylation is an important signalling mechanism in eukaryotic cells. In cancer, oncogenic activation of tyrosine kinases is a common feature, and novel anticancer drugs have been introduced that target these enzymes. Tyrosine phosphorylation is also controlled by protein-tyrosine phosphatases (PTPs). Recent evidence has shown that PTPs can function as tumour suppressors. In addition, some PTPs, including SHP2, positively regulate the signalling of growth-factor receptors, and can be oncogenic. An improved understanding of how these enzymes function and how they are regulated might aid the development of new anticancer agents.

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页码：307 / 320

页数：14

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