The best process was determined through determination in different temperature of polysaccharide completely dissolved time, the precipitation coefficient after standing some of the different time and the filtering effect of different filter medium. The Coriolan oral liquid was trial produce by the best technology and its quality was tested. The result was showed that the best dissolved time of polysaccharide was 80 degrees C, and the best standing time was 24 h of polysaccharide solution, and the best filter medium was a layer of Cotton wool. The result of quality test was in line with national standards about density, pH value, color reaction, polysaccharide content and microorganism content. The final quality level of Coriolan oral liquid was that properties was brown liquid and the tast was sweet, while relative density was 1.048-1.058, but pH value was 6.7-6.9 and the content of polysaccharide of Coriolan was 32.86-33.21. Coriolus is extracted from Polystictus versi-color (L.) protein polysaccharide extracted by Fr., mainly composed of dextran, and contains 5 kinds of other types of sugar (xylose, galactose, mannose, in Li Tang, Arabia, sugar) from mycelia cultured in the body can also be isolated from Coriolus versicolor polysaccharide. Since 1965, Japanese scientists began to introduce polysaccharide anti-tumor research field has been a full 40 years of history, modern pharmacological research shows that polysaccharide has significant anti-tumor, anti-ulcer, liver protection, antiviral, hypolipidemic and immune regulation for. PSK products currently on the market mainly for granules. In 1980s, it is widely in the country when the outbreak of hepatitis A. Since the absorption of the tablets is slower after the oral administration, the granules are affected by certain environmental factors. Therefore, the oral liquid is changed into oral liquid so as to promote absorption, convenient drinking and enhancing curative effect.