Intramolecular DNA coiling mediated by metallosupramolecular cylinders: Differential binding of P and M helical enantiomers

被引：174

作者：

Meistermann, I

Moreno, V

Prieto, MJ

Moldrheim, E

Sletten, E

Khalid, S

Rodger, PM

Peberdy, JC

Isaac, CJ

Rodger, A ^{[1
]}

Hannon, MJ

机构：

[1] Univ Warwick, Dept Chem, Coventry CV4 7AL, W Midlands, England

[2] Univ Barcelona, Dept Quim Inorgan, E-08028 Barcelona, Spain

[3] Univ Bergen, Dept Chem, N-5007 Bergen, Norway

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 2002年 / 99卷 / 08期

关键词：

D O I：

10.1073/pnas.062634499

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

We have designed a synthetic tetracationic metallo-supramolecular cylinder that targets the major groove of DNA with a binding constant in excess of 10(7) M-1 and induces DNA bending and intramolecular coiling. The two enantiomers of the helical molecule bind differently to DNA and have different structural effects. We report the characterization of the interactions by a range of biophysical techniques. The M helical cylinder binds to the major groove and induces dramatic intramolecular coiling. The DNA bending is less dramatic for the P enantiomer.

引用

页码：5069 / 5074

页数：6

共 23 条

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