Synergistic effect of combined treatment with gamma-tocotrienol and statin on human malignant mesothelioma cells

被引：16
|
作者：
Tuerdi, Guligena [1 ]
Ichinomiya, Saki [1 ]
Sato, Hiromi [1 ]
Siddig, Sana [1 ]
Suwa, Eriko [1 ]
Iwata, Hiroki [1 ]
Yano, Tomohiro [2 ]
Ueno, Koichi [1 ]
机构：
[1] Chiba Univ, Grad Sch Pharmaceut Sci, Dept Geriatr Pharmacol & Therapeut, Chuo Ku, Chiba 2608675, Japan
[2] Toyo Univ, Fac Life Sci, Itakura, Gunma 3740193, Japan
来源：
CANCER LETTERS | 2013年 / 339卷 / 01期
关键词：
Gamma tocotrienol; Statin; Mesothelioma; Mevalonate pathway; Apoptosis; CISPLATIN-INDUCED CYTOTOXICITY; COENZYME-A REDUCTASE; BREAST-CANCER CELLS; CASPASE-3; ACTIVATION; PLEURAL MESOTHELIOMA; MEVALONATE PATHWAY; INDUCED APOPTOSIS; HUMAN LIVER; RECEPTOR; INHIBITION;
D O I：
10.1016/j.canlet.2013.07.015
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The present study is the first to demonstrate the synergetic effect of statins (atorvastatin and simvastatin) and gamma-tocotrienol (gamma-T3) on human malignant mesothelioma (MM). Statin + gamma-T3 combinations induced greater cell growth inhibition more than each single treatment via inhibition of mevalonate pathway, a well-known target of both gamma-T3 and statins. gamma-T3 was necessary for endoplasmic reticulum stress markers CHOP and GRP78, whereas an intrinsic apoptotic marker, caspase 3 activation was induced only in the presence of statins. Overall, the combination of gamma-T3 and statins could be useful for MM therapy and functions in a complementary style. (C) 2013 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码：116 / 127
页数：12
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