A case of acquired dysfibrinogenemia in multiple myeloma treated with therapeutic plasma exchange

被引：9

作者：

Post, Ginell R. ^{[1
]}

James, Lindsey ^{[1
]}

Alapat, Daisy ^{[1
]}

Guillory, Virginia ^{[1
]}

Cottler-Fox, Michele ^{[1
]}

Nakagawa, Mayumi ^{[1
]}

机构：

[1] Univ Arkansas Med Sci, Dept Pathol, Little Rock, AR 72205 USA

来源：

TRANSFUSION AND APHERESIS SCIENCE | 2013年 / 48卷 / 01期

关键词：

Multiple myeloma; Monoclonal gammopathy; Therapeutic plasma exchange; Bleeding; FACTOR-X DEFICIENCY; BLEEDING DISORDER; AMYLOIDOSIS; PATIENT; PLASMAPHERESIS; INHIBITOR; DIATHESIS; THROMBIN; PROTEIN; LEVEL;

D O I：

10.1016/j.transci.2012.06.021

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

A 70 year old Caucasian woman with IgG lamda multiple myeloma presented with uncontrollable bleeding from a bone marrow biopsy site which started days after the procedure. The patient was hyperviscous, and coagulation tests showed elevated activated partial thromboplastin time (aPTT) which was not corrected with a mixing study, elevated thrombin time and reptilase time, and possible inhibitors to Factors VIII and IX. Therapeutic plasma exchange was performed using plasma with corrections of plasma viscosity (1.6 to 1.1 centipoise) and aPTT (50 to 42.1 s) observed. The bleeding was controlled, and purified IgG demonstrated dysfibrinogenemic effects of the patient's paraprotein. (C) 2012 Elsevier Ltd. All rights reserved.

引用

页码：35 / 38

页数：4

共 27 条

[1]

Bohler A, 1999, Ther Umsch, V56, P491, DOI 10.1024/0040-5930.56.9.491

[2] PROLONGATION OF THROMBIN AND REPTILASE TIMES IN PATIENTS WITH AMYLOIDOSIS AND ACQUIRED FACTOR-X DEFICIENCY [J].

BUTLER, WM ;

BALDWIN, PE .

SOUTHERN MEDICAL JOURNAL, 1984, 77 (05) :648-651

[3] Identification of a monoclonal thrombin inhibitor associated with multiple myeloma and a severe bleeding disorder [J].

Colwell, NS ;

Tollefsen, DM ;

Blinder, MA .

BRITISH JOURNAL OF HAEMATOLOGY, 1997, 97 (01) :219-226

[4]

Cunningham MT, 2002, ARCH PATHOL LAB MED, V126, P499

[5] A MYELOMA PARAPROTEIN WITH SPECIFICITY FOR PLATELET GLYCOPROTEIN-IIIA IN A PATIENT WITH A FATAL BLEEDING DISORDER [J].

DIMINNO, G ;

CORAGGIO, F ;

CERBONE, AM ;

CAPITANIO, AM ;

MANZO, C ;

SPINA, M ;

SCARPATO, P ;

DATTOLI, GMR ;

MATTIOLI, PL ;

MANCINI, M .

JOURNAL OF CLINICAL INVESTIGATION, 1986, 77 (01) :157-164

[6] REPTILASE -R - NEW REAGENT IN BLOOD COAGULATION [J].

FUNK, C ;

GMUR, J ;

HEROLD, R ;

STRAUB, PW .

BRITISH JOURNAL OF HAEMATOLOGY, 1971, 21 (01) :43-&

[7] MECHANISM OF FACTOR-X DEFICIENCY IN SYSTEMIC AMYLOIDOSIS [J].

FURIE, B ;

VOO, L ;

MCADAM, KPWJ ;

FURIE, BC .

NEW ENGLAND JOURNAL OF MEDICINE, 1981, 304 (14) :827-830

[8]

GODAL HC, 1965, SCAND J CLIN LAB INV, VS 17, P133

[9]

GORSKI J, 1993, HAEMATOLOGIA, V25, P131

[10] MULTIPLE-MYELOMA WITH POLYNEUROPATHY AND COAGULOPATHY - A CASE-REPORT OF THE POLYNEUROPATHY, ORGANOMEGALY, ENDOCRINOPATHY, M-PROTEIN, AND SKIN CHANGE (POEMS) SYNDROME [J].

HYMAN, BT ;

WESTRICK, MA .

ARCHIVES OF INTERNAL MEDICINE, 1986, 146 (05) :993-994

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