Congenital Hypothyroidism

被引：95

作者：

Wassner, Ari J. ^{[1
]}

机构：

[1] Harvard Med Sch, Boston Childrens Hosp, Div Endocrinol, Thyroid Program, 300 Longwood Ave, Boston, MA 02115 USA

来源：

CLINICS IN PERINATOLOGY | 2018年 / 45卷 / 01期

关键词：

Congenital hypothyroidism; Neonatal thyroid; Development; Leyothyroxine; Dysgenesis; Dyshormonogenesis; THYROID-HORMONE REPLACEMENT; COGNITIVE-DEVELOPMENT; REFERENCE INTERVALS; DUOX2; MUTATIONS; SOY FORMULA; THYROTROPIN; CHILDREN; THYROXINE; OUTCOMES; INFANTS;

D O I：

10.1016/j.clp.2017.10.004

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

Congenital hypothyroidism is common and can cause severe neurodevelopmental morbidity. Prompt diagnosis and treatment are critical to optimizing long-term outcomes. Universal newborn screening is an important tool for detecting congenital hypothyroidism, but awareness of its limitations, repeated screening in high-risk infants, and a high index of clinical suspicion are needed to ensure that all affected infants are appropriately identified and treated. Careful evaluation will usually reveal the etiology of congenital hypothyroidism, which may inform treatment and prognosis. Early and adequate treatment with levothyroxine results in excellent neurodevelopmental outcomes for most patients with congenital hypothyroidism.

引用

页码：1 / +

页数：19

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