Cyclic peroxides as promising anticancer agents: in vitro cytotoxicity study of synthetic ozonides and tetraoxanes on human prostate cancer cell lines

被引：41

作者：

Yaremenko, Ivan A. ^{[1
,2
]}

Syroeshkin, Mikhail A. ^{[1
]}

Levitsky, Dmitri O. ^{[2
,3
]}

Fleury, Fabrice ^{[3
]}

Terent'ev, Alexander O. ^{[1
,2
]}

机构：

[1] Russian Acad Sci, Zelinsky Inst Organ Chem, Leninsky Prospect 47, Moscow 119991, Russia

[2] All Russian Res Inst Phytopathol, Vyazemskii 143050, Moscow Region, Russia

[3] Univ Nantes, Mech & Regulat DNA Repair Team, UFIP CNRS UMR 6286, 2 Rue Houssiniere, F-44322 Nantes, France

来源：

MEDICINAL CHEMISTRY RESEARCH | 2017年 / 26卷 / 01期

基金：

俄罗斯科学基金会;

关键词：

Ozonide; Tetraoxane; Peroxide; Cytotoxicity; Prostate; Cancer; HUMAN LEUKEMIA-CELLS; HYDROGEN-PEROXIDE; ARTEMISININ DERIVATIVES; ANTIMALARIAL PEROXIDES; TRIOXANE DIMERS; DRUG DISCOVERY; BRIDGED 1,2,4,5-TETRAOXANES; GEMINAL BISHYDROPEROXIDES; ENOL ETHERS; 1,2,4-TRIOXANES;

D O I：

10.1007/s00044-016-1736-2

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Synthetic ozonides and tetraoxanes were shown to have high cytotoxicity in vitro when tested on androgen-independent prostate cancer cell lines DU145 and PC3, which is in some cases was higher than that of doxorubicin, cisplatin, etoposide, artemisinin, and artesunate. Activity of ozonide stereoisomers differs from each other. This difference in activity and absence of correlation between activity of stereoisomers and their oxidative properties allow us to suggest existence of a quite specific mechanism of cytotoxicity of these endoperoxides different from a traditional mechanism based mainly on oxidative properties of peroxides.

引用

页码：170 / 179

页数：10

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