Ruthenium-Catalyzed Gram-Scale Preferential C-H Arylation of Tertiary Phosphine

被引：36

作者：

Li, Jia-Wei ^{[1
,2
]}

Wang, Liang-Neng ^{[1
,2
]}

Li, Ming ^{[1
,2
]}

Tang, Pan-Ting ^{[1
,2
]}

Luo, Xiao-Peng ^{[1
,2
]}

Kurmoo, Mohamedally ^{[4
]}

Liu, Yue-Jin ^{[1
,2
]}

Zeng, Ming-Hua ^{[1
,2
,3
]}

机构：

[1] Hubei Univ, Hubei Collaborat Innovat Ctr Adv Chem Mat, Key Lab Synth & Applicat Organ Funct Mol, Minist Educ, Wuhan 430062, Hubei, Peoples R China

[2] Hubei Univ, Coll Chem & Chem Engn, Wuhan 430062, Hubei, Peoples R China

[3] Guangxi Normal Univ, Dept Key Lab Chem & Mol Engn Med Resources, Sch Chem & Pharmaceut Sci, Guilin 541004, Peoples R China

[4] Univ Strasbourg, CNRS, Inst Chim Strasbourg, UMR7177, 4 Rue Blaise Pascal, F-67070 Strasbourg, France

来源：

ORGANIC LETTERS | 2019年 / 21卷 / 08期

基金：

美国国家科学基金会;

关键词：

D O I：

10.1021/acs.orglett.9b00888

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A general protocol for site-preferential mono-C-H arylation of tertiary phosphine ligands catalyzed by a ruthenium(II) complex was devised. This protocol gives access to a series of modified Buchwald-biaryl monophosphines on a gram scale in moderate to excellent yields. A catalytic cycle is proposed derived from knowledge of the intermediates observed by ESI-MS. Importantly, these monoarylated products could be further transformed into dibenzophosphole derivatives.

引用

页码：2885 / 2889

页数：5

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