Plasma Aβ42/40 Ratio Detects Early Stages of Alzheimer's Disease and Correlates with CSF and Neuroimaging Biomarkers in the AB255 Study

被引：69

作者：

Perez-Grijalba, V ^{[1
]}

Romero, J. ^{[1
]}

Pesini, P. ^{[1
]}

Sarasa, L. ^{[1
]}

Monleon, I ^{[1
]}

San-Jose, I ^{[1
]}

Arbizu, J. ^{[2
]}

Martinez-Lage, P. ^{[3
,4
]}

Munuera, J. ^{[5
]}

Ruiz, A. ^{[6
,7
]}

Tarraga, L. ^{[6
,7
]}

Boada, M. ^{[6
,7
]}

Sarasa, M. ^{[1
]}

Goni, Miguel ^{[8
]}

Pujadas, Francesc ^{[9
]}

Villarejo, Alberto ^{[10
]}

Frank, Ana ^{[11
]}

Pena-Casanova, Jordi ^{[12
]}

Fernandez, Manuel ^{[13
]}

Pinol, Gerard ^{[14
]}

Blesa, Rafael ^{[15
]}

Gil, Pedro ^{[16
]}

Pascual, Luis F. ^{[17
]}

Aguilar, Miguel ^{[18
]}

Frisoni, Giovanni B. ^{[19
]}

Matias-Guiu, Jorge ^{[16
]}

Andreasen, Niels ^{[10
]}

Antunez, Carmen ^{[20
]}

Vellas, Bruno ^{[21
]}

Touchon, Jacques ^{[22
]}

机构：

[1] Aradon Biotech SL, Zaragoza, Spain

[2] Clin Univ Navarra, Serv Med Nucl, Pamplona, Spain

[3] Fdn CITA Alzheimer, Ctr Res & Adv Therapies, San Sebastian, Spain

[4] Fdn CITA Alzheimer, Memory Clin, San Sebastian, Spain

[5] Hosp Infantil St Joan Deu, Inst Recerca St Joan Deu, Barcelona, Spain

[6] Fundacio ACE, Inst Catala Neurociencies Aplicades, Alzheimer Res Ctr, Barcelona, Spain

[7] Fundacio ACE, Inst Catala Neurociencies Aplicades, Memory Clin, Barcelona, Spain

[8] Hosp Divino Valles, Burgos, Spain

[9] Hosp Univ Vall dHebron, Barcelona, Spain

[10] Hosp Doce Octubre, Madrid, Spain

[11] Hosp La Paz, Madrid, Spain

[12] Hosp Mar, Barcelona, Spain

[13] CAE Oroitu Algorta, Vizcaya, Spain

[14] Hosp Santa Maria de Lleida, Lleida, Spain

[15] Hosp Santa Creu & Sant Pau, Barcelona, Spain

[16] Hosp Clin San Carlos, Madrid, Spain

[17] Hosp Lozano Blesa, Zaragoza, Spain

[18] Hosp Univ Mutua Terrassa, Terrassa, Spain

[19] IRCCS Ctr San Giovanni Dio FBF, Brescia, Italy

[20] Fdn Alzheimur, Hosp Virgen de la Arrixaca, Murcia, Spain

[21] Hop CHU La Grave, Toulouse, France

[22] CHU, Hop Gui de Chauliac, Montpellier, France

来源：

JPAD-JOURNAL OF PREVENTION OF ALZHEIMERS DISEASE | 2019年 / 6卷 / 01期

关键词：

beta-amyloid (A beta); Alzheimer's disease; plasma; biomarker; A beta ratio; MILD COGNITIVE IMPAIRMENT; AMYLOID-BETA LEVELS; CEREBROSPINAL-FLUID; RISK; ASSOCIATION; DEMENTIA; DIAGNOSIS; TRIALS; PET; A-BETA(42);

D O I：

10.14283/jpad.2018.41

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

BACKGROUND: Easily accessible biomarkers are needed for the early identification of individuals at risk of developing Alzheimer's disease (AD) in large population screening strategies. OBJECTIVES: This study evaluated the potential of plasma beta-amyloid (A beta) biomarkers in identifying early stages of AD and predicting cognitive decline over the following two years. DESIGN: Total plasma A beta 42/40 ratio (TP42/40) was determined in 83 cognitively normal individuals (CN) and 145 subjects with amnestic mild cognitive impairment (a-MCI) stratified by an FDG-PET AD-risk pattern. RESULTS: Significant lower TP42/40 ratio was found in a-MCI patients compared to CN. Moreover, a-MCIs with a high-risk FDG-PET pattern for AD showed even lower plasma ratio levels. Low TP42/40 at baseline increased the risk of progression to dementia by 70%. Furthermore, TP42/40 was inversely associated with neocortical amyloid deposition (measured with PiB-PET) and was concordant with the AD biomarker profile in cerebrospinal fluid (CSF). CONCLUSIONS: TP42/40 demonstrated value in the identification of individuals suffering a-MCI, in the prediction of progression to dementia, and in the detection of underlying AD pathology revealed by FDG-PET, Amyloid-PET and CSF biomarkers, being, thus, consistently associated with all the well-established indicators of AD.

引用

页码：34 / 41

页数：8

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