Boesenbergia rotunda: From Ethnomedicine to Drug Discovery

被引：81

作者：

Eng-Chong, Tan ^{[1
,2
]}

Yean-Kee, Lee ^{[2
,3
]}

Chin-Fei, Chee ^{[2
,3
,4
]}

Choon-Han, Heh ^{[2
,3
,5
]}

Sher-Ming, Wong ^{[6
,7
]}

Li-Ping, Christina Thio ^{[1
,2
,6
]}

Gen-Teck, Foo ^{[2
,7
]}

Khalid, Norzulaani ^{[6
,7
]}

Abd Rahman, Noorsaadah ^{[2
,3
]}

Karsani, Saiful Anuar ^{[2
,6
]}

Othman, Shatrah ^{[1
,2
]}

Othman, Rozana ^{[2
,5
]}

Yusof, Rohana ^{[1
,2
]}

机构：

[1] Univ Malaya, Dept Mol Med, Fac Med, Kuala Lumpur 50603, Malaysia

[2] Univ Malaya, Drug Design & Dev Res Grp DDDRG, Kuala Lumpur 50603, Malaysia

[3] Univ Malaya, Dept Chem, Fac Sci, Kuala Lumpur 50603, Malaysia

[4] Int Med Univ IMU, Div Pharm, Sch Pharm & Hlth Sci, Kuala Lumpur 57000, Malaysia

[5] Univ Malaya, Dept Pharm, Fac Med, Kuala Lumpur 50603, Malaysia

[6] Univ Malaya, Inst Biol Sci, Fac Sci, Kuala Lumpur 50603, Malaysia

[7] Univ Malaya, Biotechnol & Bioprod Res Cluster UMBIO, Kuala Lumpur 50603, Malaysia

来源：

EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE | 2012年 / 2012卷

关键词：

CYCLOHEXENYL CHALCONE DERIVATIVES; L; MANSF; KULTURPFL; DIELS-ALDER REACTION; KAEMPFERIA-PANDURATA; MEDICINAL-PLANTS; STEREOSELECTIVE-SYNTHESIS; SECONDARY METABOLISM; BLACK RHIZOMES; AIDS PATIENTS; RED RHIZOMES;

D O I：

10.1155/2012/473637

中图分类号：

R [医药、卫生];

学科分类号：

10 ;

摘要：

Boesenbergia rotunda is a herb from the Boesenbergia genera under the Zingiberaceae family. B. rotunda is widely found in Asian countries where it is commonly used as a food ingredient and in ethnomedicinal preparations. The popularity of its ethnomedicinal usage has drawn the attention of scientists worldwide to further investigate its medicinal properties. Advancement in drug design and discovery research has led to the development of synthetic drugs from B. rotunda metabolites via bioinformatics and medicinal chemistry studies. Furthermore, with the advent of genomics, transcriptomics, proteomics, and metabolomics, new insights on the biosynthetic pathways of B. rotunda metabolites can be elucidated, enabling researchers to predict the potential bioactive compounds responsible for the medicinal properties of the plant. The vast biological activities exhibited by the compounds obtained from B. rotunda warrant further investigation through studies such as drug discovery, polypharmacology, and drug delivery using nanotechnology.

引用

页数：25

共 122 条

[1] The methanolic extract of Boesenbergia rotunda (L.) Mansf. and its major compound pinostrobin induces anti-ulcerogenic property in vivo: Possible involvement of indirect antioxidant action [J].