The design of polyvalent therapeutics

被引：57

作者：

Joshi, Amit ^{[1
]}

Vance, David ^{[1
]}

Rai, Prakash ^{[1
]}

Thiyagarajan, Aditya ^{[1
]}

Kane, Ravi S. ^{[1
]}

机构：

[1] Rensselaer Polytech Inst, Howard P Isermann Dept Chem & Biol Engn, Troy, NY 12180 USA

来源：

CHEMISTRY-A EUROPEAN JOURNAL | 2008年 / 14卷 / 26期

关键词：

drug delivery; imaging agents; immunology; inhibitors; polyvalency;

D O I：

10.1002/chem.200800278

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

This article reviews recent developments in the design of polyvalent ligands for in vivo applications. Topics discussed include the design of polyvalent inhibitors of toxins and viruses, the use of polyvalency for targeted drug delivery and imaging, and applications of polyvalency for enhancing or suppressing immune responses.

引用

页码：7738 / 7747

页数：10

共 89 条

[1] Nanocrystal targeting in vivo [J].

Åkerman, ME ;

Chan, WCW ;

Laakkonen, P ;

Bhatia, SN ;

Ruoslahti, E .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 (20) :12617-12621

[2] Polymers carrying sLex-mimetics are superior inhibitors of E-selectin-dependent leukocyte rolling in vivo [J].

Ali, M ;

Hicks, AER ;

Hellewell, PG ;

Thoma, G ;

Norman, KE .

FASEB JOURNAL, 2004, 18 (01) :152-154

[3] Cancer treatment by targeted drug delivery to tumor vasculature in a mouse model [J].

Arap, W ;

Pasqualini, R ;

Ruoslahti, E .

SCIENCE, 1998, 279 (5349) :377-380

[4] Polyvalent inhibitors of anthrax toxin that target host receptors [J].

Bashat, Saleem ;

Rai, Prakash ;

Poon, Vincent ;

Saraph, Arundhati ;

Gujraty, Kunal ;

Go, Mandy Y. ;

Sadacharan, Skanda ;

Frost, Mia ;

Mogridge, Jeremy ;

Kane, Ravi S. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2006, 103 (36) :13509-13513

[5] Engineering novel binding proteins from nonimmunoglobulin domains [J].

Binz, HK ;

Amstutz, P ;

Plückthun, A .

NATURE BIOTECHNOLOGY, 2005, 23 (10) :1257-1268

[6] Administration of GAS914 in an orthotopic pig-to-baboon heart transplantation model [J].

Brandl, U ;

Michel, S ;

Erhardt, M ;

Brenner, P ;

Bittmann, I ;

Rössle, M ;

Baschnegger, H ;

Bauer, A ;

Hammer, C ;

Schmoeckel, M ;

Reichart, B .

XENOTRANSPLANTATION, 2005, 12 (02) :134-141

[7] Soluble Galα(1,3)Gal conjugate combined with hDAF preserves morphology and improves function of cardiac xenografts [J].

Brandl, Ulrike ;

Erhardt, Matthias ;

Michel, Sebastian ;

Joeckle, Hannah ;

Burdorf, Lars ;

Bittmann, Iris ;

Roessle, Matthias ;

Mordstein, Volker ;

Brenner, Paolo ;

Hammer, Claus ;

Reichart, Bruno ;

Schmoeckel, Michael .

XENOTRANSPLANTATION, 2007, 14 (04) :323-332

[8] Peptide-labeled near-infrared quantum dots for imaging tumor vasculature in living subjects [J].

Cai, WB ;

Shin, DW ;

Chen, K ;

Gheysens, O ;

Cao, QZ ;

Wang, SX ;

Gambhir, SS ;

Chen, XY .

NANO LETTERS, 2006, 6 (04) :669-676

[9] Selective tumor cell targeting using low-affinity, multivalent interactions [J].

Carlson, Coby B. ;

Mowery, Patricia ;

Owen, Robert M. ;

Dykhuizen, Emily C. ;

Kiessling, Laura L. .

ACS CHEMICAL BIOLOGY, 2007, 2 (02) :119-127

[10] Carbohydrates in transplantation [J].

Chen, X ;

Andreana, PR ;

Wang, PG .

CURRENT OPINION IN CHEMICAL BIOLOGY, 1999, 3 (06) :650-658

← 1 2 3 4 5 6 7 8 9 →