Ultrasound-Assisted Synthesis and Characterization of Heparin-Coated Eu3+ Doped Hydroxyapatite Luminescent Nanoparticles

被引：27

作者：

Xing, Qingguo ^{[1
]}

Zhang, Xiaojun ^{[1
]}

Wu, Dulan ^{[2
]}

Han, Yingchao ^{[1
]}

Wickramaratne, M. Nirmali ^{[3
]}

Dai, Honglian ^{[1
]}

Wang, Xinyu ^{[1
]}

机构：

[1] Wuhan Univ Technol, State Key Lab Adv Technol Mat Synth & Proc, Biomed Mat & Engn Res Ctr Hubei Prov, Wuhan 430070, Hubei, Peoples R China

[2] Wuhan Univ Technol, Int Sch Mat Sci & Engn, Wuhan 430070, Hubei, Peoples R China

[3] Sabaragamuwa Univ Sri Lanka, Fac Sci Appl, Belihuloya 70140, Sri Lanka

来源：

COLLOID AND INTERFACE SCIENCE COMMUNICATIONS | 2019年 / 29卷

基金：

中国国家自然科学基金;

关键词：

Hydroxyapatite nanoparticles; Heparin; Europium; Luminescence; Bioimaging; CALCIUM-PHOSPHATE NANOPARTICLES; RARE-EARTH-ELEMENTS; APATITE; NANOCRYSTALS; COMPOSITES; BIOAPATITE; DELIVERY;

D O I：

10.1016/j.colcom.2019.01.001

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

Herein, the heparin-coated Eu3+ doped hydroxyapatite luminescent nanoparticles were synthesized by an ultrasound- assisted coprecipitation method followed with steam sterilization at 121 degrees C. The effects of ultrasound treatment, steam sterilization, sodium heparin (SH) concentration and Eu doping content on the formation of heparin-coated Eu3+ doped hydroxyapatite nanoparticles (SH-Eu:nHAP) were investigated. The sterilized and suspended Eu-nHAP with improved luminescence and stability was simultaneously achieved in a process of about 2 h due to the combined effect of ultrasonic sonochemistry and stabilization function of SH. The obtained SH-Eu:nHAP suspension shows good stability in water and biological media. Moreover, the SH-Eu: nHAP shows no hemolysis and cytotoxicity, and can be ingested by cells and emit characteristic luminescence in cells. In summary, this study provides an improved method for the synthesis of SH-Eu: nHAP suspension that is helpful for promoting the application of rare earth doped nHAP as bioimaging agent.

引用

页码：17 / 25

页数：9

共 34 条

[1] Preparation and Physicochemical Characteristics of Luminescent Apatite-Based Colloids [J].