Hexamollamide, a hexapeptide from an Okinawan ascidian Didemnum molle

被引：19
作者：
Teruya, Toshiaki [1 ]
Sasaki, Hiroaki [1 ]
Suenaga, Kiyotake [1 ]
机构：
[1] Keio Univ, Fac Sci & Technol, Dept Chem, Kohoku Ku, Yokohama, Kanagawa 2238522, Japan
来源：
TETRAHEDRON LETTERS | 2008年 / 49卷 / 36期
关键词：
D O I：
10.1016/j.tetlet.2008.06.086
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The bioassay-guided fractionation of the cytotoxic constituents of the Okinawan ascidian Didemnum molle led to the isolation of hexamollamide (1), a hexapeptide. The gross structure and relative stereostructure of 1 were established by spectroscopic analysis including 2D NMR techniques and single-crystal X-ray diffraction analysis. The absolute stereostructure was determined by chiral HPLC analysis of acid hydrolysates of 1. Hexamollamide (1) exhibits moderate cytotoxicity against HeLa S-3 cells. (C) 2008 Elsevier Ltd. All rights reserved.
引用
收藏
页码：5297 / 5299
页数：3
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