Hexamollamide, a hexapeptide from an Okinawan ascidian Didemnum molle

被引：19

作者：

Teruya, Toshiaki ^{[1
]}

Sasaki, Hiroaki ^{[1
]}

Suenaga, Kiyotake ^{[1
]}

机构：

[1] Keio Univ, Fac Sci & Technol, Dept Chem, Kohoku Ku, Yokohama, Kanagawa 2238522, Japan

来源：

TETRAHEDRON LETTERS | 2008年 / 49卷 / 36期

关键词：

D O I：

10.1016/j.tetlet.2008.06.086

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The bioassay-guided fractionation of the cytotoxic constituents of the Okinawan ascidian Didemnum molle led to the isolation of hexamollamide (1), a hexapeptide. The gross structure and relative stereostructure of 1 were established by spectroscopic analysis including 2D NMR techniques and single-crystal X-ray diffraction analysis. The absolute stereostructure was determined by chiral HPLC analysis of acid hydrolysates of 1. Hexamollamide (1) exhibits moderate cytotoxicity against HeLa S-3 cells. (C) 2008 Elsevier Ltd. All rights reserved.

引用

页码：5297 / 5299

页数：3

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