Hexamollamide, a hexapeptide from an Okinawan ascidian Didemnum molle

被引:19
|
作者
Teruya, Toshiaki [1 ]
Sasaki, Hiroaki [1 ]
Suenaga, Kiyotake [1 ]
机构
[1] Keio Univ, Fac Sci & Technol, Dept Chem, Kohoku Ku, Yokohama, Kanagawa 2238522, Japan
关键词
D O I
10.1016/j.tetlet.2008.06.086
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
The bioassay-guided fractionation of the cytotoxic constituents of the Okinawan ascidian Didemnum molle led to the isolation of hexamollamide (1), a hexapeptide. The gross structure and relative stereostructure of 1 were established by spectroscopic analysis including 2D NMR techniques and single-crystal X-ray diffraction analysis. The absolute stereostructure was determined by chiral HPLC analysis of acid hydrolysates of 1. Hexamollamide (1) exhibits moderate cytotoxicity against HeLa S-3 cells. (C) 2008 Elsevier Ltd. All rights reserved.
引用
收藏
页码:5297 / 5299
页数:3
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