Predicting lead relative bioavailability in peri-urban contaminated soils using in vitro bioaccessibility assays

被引：34

作者：

Juhasz, Albert L. ^{[1
,2
]}

Smith, Euan ^{[1
,2
]}

Weber, John ^{[1
,2
]}

Rees, Matthew ^{[3
]}

Kuchel, Tim ^{[3
]}

Rofe, Allan ^{[3
]}

Sansom, Lloyd ^{[4
]}

Naidu, Ravi ^{[1
,2
]}

机构：

[1] Univ S Australia, Ctr Environm Risk Assessment & Remediat, Adelaide, SA 5095, Australia

[2] Cooperat Res Ctr Contaminat Assessment & Remediat, Adelaide, SA, Australia

[3] SA Pathol Inst Med & Vet Sci, Vet Serv Div, Gilles Plains, SA, Australia

[4] Univ S Australia, Sch Pharm & Med Sci, Sansom Inst, Adelaide, SA 5095, Australia

来源：

JOURNAL OF ENVIRONMENTAL SCIENCE AND HEALTH PART A-TOXIC/HAZARDOUS SUBSTANCES & ENVIRONMENTAL ENGINEERING | 2013年 / 48卷 / 06期

关键词：

Bioaccessibility; in vitro; in vivo; lead; relative bioavailability; VALIDATION; EXPOSURE; CADMIUM; EXTRACTION; RELEVANT; CHILDREN; SMELTER; CANADA; METAL; DUST;

D O I：

10.1080/10934529.2013.731354

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

In this study, lead (Pb) bioaccessibility was assessed in peri-urban contaminated soils using a variety of established in vitro assays. Bioaccessibility data was then used to predict Pb relative bioavailability (RBA) using published in vivo-in vitro regression models in order to compare calculated estimates and measured values. Lead bioaccessibility varied depending on the in vitro methodology employed with the relative bioavailability leaching procedure (RBALP) and in vitro gastrointestinal (IVG) assays providing more conservative Pb bioaccessibility values compared to those determined using PBET, UBM and Rel-SBRC-I assays. When Pb RBA was calculated, predicted values using PBET-G and UBM-G data were similar to measured Pb RBA values. However, Pb RBA was over-estimated by 1.65.5- and 2.66.6-fold when data and regression models from RBALP and IVG-G assays were employed.

引用

页码：604 / 611

页数：8

共 26 条

[1]

Agency for Toxic Substances and Diseases Registry, 2007, PRIOR LIST HAZ SUBST

[2]

[Anonymous], 2007, OSWER, V9285, P7

[3]

[Anonymous], 1999, NATL ASS SCH EXCELLE, P1

[4] Do current standards of practice in Canada measure what is relevant to human exposure at contaminated sites? I: A discussion of soil particle size and contaminant partitioning in soil [J].

Bright, Doug A. ;

Richardson, G. Mark ;

Dodd, Matt .

HUMAN AND ECOLOGICAL RISK ASSESSMENT, 2006, 12 (03) :591-605

[5] Bioavailability of lead to juvenile swine dosed with soil from the Smuggler Mountain NPL site of Aspen, Colorado [J].

Casteel, SW ;

Cowart, RP ;

Weis, CP ;

Henningsen, GM ;

Hoffman, E ;

Brattin, WJ ;

Guzman, RE ;

Starost, MF ;

Payne, JT ;

Stockham, SL ;

Becker, SV ;

Drexler, JW ;

Turk, JR .

FUNDAMENTAL AND APPLIED TOXICOLOGY, 1997, 36 (02) :177-187

[6] MICROMINERALOGY OF MINE WASTES IN RELATION TO LEAD BIOAVAILABILITY, BUTTE, MONTANA [J].

DAVIS, A ;

DREXLER, JW ;

RUBY, MV ;

NICHOLSON, A .

ENVIRONMENTAL SCIENCE & TECHNOLOGY, 1993, 27 (07) :1415-1425

[7] In Vivo Validation of the Unified BARGE Method to Assess the Bioaccessibility of Arsenic, Antimony, Cadmium, and Lead in Soils [J].

Denys, Sebastien ;

Caboche, Julien ;

Tack, Karine ;

Rychen, Guido ;

Wragg, Joanna ;

Cave, Mark ;

Jondreville, Catherine ;

Feidt, Cyril .

ENVIRONMENTAL SCIENCE & TECHNOLOGY, 2012, 46 (11) :6252-6260

[8] An in vitro procedure for estimation of lead relative bioavailability:: With validation [J].

Drexler, J. W. ;

Brattin, W. J. .

HUMAN AND ECOLOGICAL RISK ASSESSMENT, 2007, 13 (02) :383-401

[9] Impact of soil particle size and bioaccessibility on children and adult lead exposure in pen-urban contaminated soils [J].

Juhasz, Albert L. ;

Weber, John ;

Smith, Euan .

JOURNAL OF HAZARDOUS MATERIALS, 2011, 186 (2-3) :1870-1879

[10] Assessment of Four Commonly Employed in Vitro Arsenic Bioaccessibility Assays for Predicting in Vivo Relative Arsenic Bioavailability in Contaminated Soils [J].

Juhasz, Albert L. ;

Weber, John ;

Smith, Euan ;

Naidu, Ravi ;

Rees, Matthew ;

Rofe, Allan ;

Kuchel, Tim ;

Sansom, Lloyd .

ENVIRONMENTAL SCIENCE & TECHNOLOGY, 2009, 43 (24) :9487-9494

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