Epithelial keratins: Biology and implications as diagnostic markers for liquid biopsies

被引：56

作者：

Werner, Stefan ^{[1
]}

Keller, Laura ^{[1
]}

Pantel, Klaus ^{[1
]}

机构：

[1] Univ Med Ctr Hamburg Eppendorf, Inst Tumor Biol, Hamburg, Germany

来源：

MOLECULAR ASPECTS OF MEDICINE | 2020年 / 72卷

基金：

欧盟地平线“2020”;

关键词：

Keratins; Liquid biopsy; Circulating tumor cells; EMT; Tumor biomarker; Tumor cell dissemination; CIRCULATING TUMOR-CELLS; BREAST-CANCER PATIENTS; BONE-MARROW MICROMETASTASIS; INTERMEDIATE-FILAMENTS; DNA METHYLATION; MESENCHYMAL PLASTICITY; CYTOKERATIN EXPRESSION; CLINICAL-RELEVANCE; PERIPHERAL-BLOOD; GENE-EXPRESSION;

D O I：

10.1016/j.mam.2019.09.001

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Keratins are essential elements of the cytoskeleton of normal and malignant epithelial cells. Because carcinomas commonly maintain their specific keratin expression pattern during malignant transformation, keratins are extensively used as tumor markers in cancer diagnosis including the detection of circulating tumor cells in blood of carcinoma patients. Interestingly, recent biological insights demonstrate that epithelial keratins should not only be considered as mere tumor markers. Emerging evidence suggests an active biological role of keratins in tumor cell dissemination and metastasis. In this review, we illustrate the family of keratin proteins, summarize the latest biological insights into keratin function related to cancer metastasis and discuss the current use of keratins for detection of CTCs and other blood biomarkers used in oncology.

引用

页数：11

共 124 条

[1] Circulating Tumor Cell Clusters Are Oligoclonal Precursors of Breast Cancer Metastasis [J].

Aceto, Nicola ;

Bardia, Aditya ;

Miyamoto, David T. ;

Donaldson, Maria C. ;

Wittner, Ben S. ;

Spencer, Joel A. ;

Yu, Min ;

Pely, Adam ;

Engstrom, Amanda ;

Zhu, Huili ;

Brannigan, Brian W. ;

Kapur, Ravi ;

Stott, Shannon L. ;

Shioda, Toshi ;

Ramaswamy, Sridhar ;

Ting, David T. ;

Lin, Charles P. ;

Toner, Mehmet ;

Haber, Daniel A. ;

Maheswaran, Shyamala .

CELL, 2014, 158 (05) :1110-1122

[2] Preoperative serum tissue polypeptide-specific antigen is a valuable prognostic marker in breast cancer [J].

Ahn, Soo Kyung ;

Moon, Hyeong-Gon ;

Ko, Eunyoung ;

Kim, Han Suk ;

Shin, Hee-Chul ;

Kim, Jisun ;

You, Jee Man ;

Han, Wonshik ;

Noh, Dong-Young .

INTERNATIONAL JOURNAL OF CANCER, 2013, 132 (04) :875-881

[3] Keratin 8 modulates β-cell stress responses and normoglycaemia [J].

Alam, Catharina M. ;

Silvander, Jonas S. G. ;

Daniel, Ebot N. ;

Tao, Guo-Zhong ;

Kvarnstrom, Sofie M. ;

Alam, Parvez ;

Omary, M. Bishr ;

Hanninen, Arno ;

Toivola, Diana M. .

JOURNAL OF CELL SCIENCE, 2013, 126 (24) :5635-5644

[4] Epithelial-mesenchymal plasticity in circulating tumor cells [J].

Alix-Panabieres, Catherine ;

Mader, Sonja ;

Pantel, Klaus .

JOURNAL OF MOLECULAR MEDICINE-JMM, 2017, 95 (02) :133-142

[5] Liquid biopsy in cancer patients: advances in capturing viable CTCs for functional studies using the EPISPOT assay [J].

Alix-Panabieres, Catherine ;

Pantel, Klaus .

EXPERT REVIEW OF MOLECULAR DIAGNOSTICS, 2015, 15 (11) :1411-1417

[6] Full-length cytokeratin-19 is released by human tumor cells: a potential role in metastatic progression of breast cancer [J].

Alix-Panabieres, Catherine ;

Vendrell, Jean-Pierre ;

Slijper, Monique ;

Pelle, Olivier ;

Barbotte, Eric ;

Mercier, Gregoire ;

Jacot, William ;

Fabbro, Michel ;

Pantel, Klaus .

BREAST CANCER RESEARCH, 2009, 11 (03)

[7] Challenges in circulating tumor cell detection by the CellSearch system [J].

Andree, Kiki C. ;

van Dalum, Guus ;

Terstappen, Leon W. M. M. .

MOLECULAR ONCOLOGY, 2016, 10 (03) :395-407

[8] EMT: 2016 [J].

Angela Nieto, M. ;

Huang, Ruby Yun-Ju ;

Jackson, Rebecca A. ;

Thiery, Jean Paul .

CELL, 2016, 166 (01) :21-45

[9]

[Anonymous], 2000, Molecular Cell Biology

[10] Caspase-cleaved cytokeratin 18 fragment (M30) as marker of postoperative residual tumor load in colon cancer patients [J].

Ausch, C. ;

Buxhofer-Ausch, V. ;

Olszewski, U. ;

Hinterberger, W. ;

Ogris, E. ;

Schiessel, R. ;

Hamilton, G. .

EJSO, 2009, 35 (11) :1164-1168

← 1 2 3 4 5 6 7 8 9 10 →