Human-induced pluripotent stem cell models of inherited cardiomyopathies

被引：21

作者：

Karakikes, Ioannis ^{[1
,2
]}

Termglinchan, Vittavat ^{[1
,2
,3
]}

Wu, Joseph C. ^{[1
,2
,3
,4
]}

机构：

[1] Stanford Univ, Sch Med, Stanford Cardiovasc Inst, Stanford, CA 94305 USA

[2] Stanford Univ, Sch Med, Dept Med, Div Cardiol, Stanford, CA 94305 USA

[3] Stanford Univ, Sch Med, Dept Radiol, Stanford, CA 94305 USA

[4] Stanford Univ, Sch Med, Inst Stem Cell Biol & Regenerat Med, Stanford, CA 94305 USA

来源：

CURRENT OPINION IN CARDIOLOGY | 2014年 / 29卷 / 03期

关键词：

arrhythmogenic right ventricular cardiomyopathy; dilated cardiomyopathy; hypertrophic cardiomyopathy; induced pluripotent stem cells; inherited cardiomyopathy; RIGHT-VENTRICULAR DYSPLASIA/CARDIOMYOPATHY; FAMILIAL HYPERTROPHIC CARDIOMYOPATHY; DILATED CARDIOMYOPATHY; CARDIOMYOCYTES; DISEASE; MECHANISMS;

D O I：

10.1097/HCO.0000000000000049

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Purpose of reviewThis article provides an overview of the latest advances in in-vitro modeling of inherited cardiomyopathies using human-induced pluripotent stem cells (iPSCs).Recent findingsInherited cardiomyopathies have been recently modeled by generating iPSCs from patients harboring mutations in genes associated with the pathogenesis of hypertrophic cardiomyopathy, dilated cardiomyopathy, and arrhythmogenic right ventricular cardiomyopathy/dysplasia.SummaryPatient-specific iPSCs and their differentiated cardiomyocytes (induced pluripotent stem cell-derived cardiomyocytes) now provide a novel model to study the underlying molecular mechanism of the pathogenesis of familial cardiomyopathies as well as for in-vitro drug screening and drug discovery.

引用

页码：214 / 219

页数：6

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