Targeted Singlet Oxygen Generation Using Different DNA-Interacting Perylene Diimide Type Photosensitizers

被引：21

作者：

Dincalp, Haluk ^{[1
]}

Kizilok, Sevki ^{[1
]}

Icli, Siddik ^{[2
]}

机构：

[1] Celal Bayar Univ, Dept Chem, Fac Arts & Sci, TR-45030 Muradiye, Manisa, Turkey

[2] Ege Univ, Solar Energy Inst, TR-35100 Izmir, Turkey

来源：

JOURNAL OF FLUORESCENCE | 2014年 / 24卷 / 03期

关键词：

Perylene diimide; Pyrene; Charge transfer; G-quadruplex DNA; Singlet oxygen; DPBF method; G-QUADRUPLEX; PHOTODYNAMIC THERAPY; MOLECULAR-OXYGEN; ELECTROCHEMICAL PROPERTIES; ELECTRON-TRANSFER; EXCITED SINGLET; TRIPLET-STATES; DERIVATIVES; BINDING; PYRENE;

D O I：

10.1007/s10895-014-1372-5

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Singlet oxygen quantum yields (I broken vertical bar (Delta)) of different perylene diimides (PDIs) containing phenyl (PDI-Ph), pyrene (PDI-Pyr), and indole (PDI-In) units in bay positions of the ring were determined using 1,3-diphenylisobenzofuran (DPBF) method in toluene/methanol (99:1) system. Pyrene-substituted PDI were the most efficient singlet oxygen generator among the investigated photosensitizers with a quantum yield of I broken vertical bar (Delta) = 0.93 in toluene/methanol. Additionally, their binding affinities to G-quadruplex DNA structure were investigated by steady-state measurements. There were marked red shifts of absorbance bands for PDI-Pyr/DNA strand complexes with respect to the absorption maxima of DNA-free solution of PDI-Pyr in phosphate buffer at pH 6.

引用

页码：917 / 924

页数：8

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