Organizing Principles of Mammalian Nonsense-Mediated mRNA Decay

被引：307

作者：

Popp, Maximilian Wei-Lin ^{[1
,2
]}

Maquat, Lynne E. ^{[1
,2
]}

机构：

[1] Univ Rochester, Sch Med & Dent, Dept Biochem & Biophys, Rochester, NY 14642 USA

[2] Univ Rochester, Ctr RNA Biol, Rochester, NY 14642 USA

来源：

ANNUAL REVIEW OF GENETICS, VOL 47 | 2013年 / 47卷

关键词：

posttranscriptional gene regulation; nonsense-mediated mRNA decay; translational repression; quality control; premature termination codon; posttranslational gene regulation; ubiquitin-proteasome system; EXON-JUNCTION COMPLEX; TRANSLATION INITIATION COMPLEX; UNFOLDED PROTEIN RESPONSE; QUALITY-CONTROL; UBIQUITIN LIGASE; VIRUS RNA; MECHANISTIC INSIGHTS; UPF1; PHOSPHORYLATION; SURVEILLANCE COMPLEX; GENE-EXPRESSION;

D O I：

10.1146/annurev-genet-111212-133424

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Cells use messenger RNAs (mRNAs) to ensure the accurate dissemination of genetic information encoded by DNA. Given that mRNAs largely direct the synthesis of a critical effector of cellular phenotype, i.e., proteins, tight regulation of both the quality and quantity of mRNA is a prerequisite for effective cellular homeostasis. Here, we review nonsense-mediated mRNA decay (NMD), which is the best-characterized posttranscriptional quality control mechanism that cells have evolved in their cytoplasm to ensure transcriptome fidelity. We use protein quality control as a conceptual framework to organize what is known about NMD, highlighting overarching similarities between these two polymer quality control pathways, where the protein quality control and NMD pathways intersect, and how protein quality control can suggest new avenues for research into mRNA quality control.

引用

收藏

页码：139 / 165

页数：27

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