Determination of Viremia and Concentration of Circulating Nonstructural Protein 1 in Patients Infected with Dengue Virus in Mexico

被引：66
作者：
de la Cruz-Hernandez, Sergio I. [1 ]
Flores-Aguilar, Hilario [1 ]
Gonzalez-Mateos, Silvia [1 ]
Lopez-Martinez, Irma [1 ]
Alpuche-Aranda, Celia [1 ]
Ludert, Juan E. [2 ]
del Angel, Rosa M. [2 ]
机构：
[1] Inst Diagnost & Referencia Epidemiol, Mexico City 11340, DF, Mexico
[2] Inst Politecn Nacl, Ctr Invest & Estudios Avanzados, Dept Infect & Patogenesis Mol, Mexico City 07360, DF, Mexico
来源：
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE | 2013年 / 88卷 / 03期
关键词：
NS1; SEROTYPE; DIAGNOSIS; CORRELATE; DISEASE; ANTIGEN; MARKERS; GLYCOPROTEIN; PATHOGENESIS; KINETICS;
D O I：
10.4269/ajtmh.12-0023
中图分类号：
R1 [预防医学、卫生学];
学科分类号：
1004 ; 120402 ;
摘要：
Higher levels of viremia and circulating nonstructural protein 1 (NS1) have been associated with dengue disease severity. In this study, viremia and circulating NS1 levels were determined in 225 serum samples collected from patients in Mexico infected with dengue virus serotypes 1 and 2 (DENV-1 and DENV-2). Patients with dengue hemorrhagic fever (DHF) who were infected with DENV-1 showed higher levels of circulating NS1 than patients with dengue fever (DF) (P = 0.0175). Moreover, NS1 levels were higher in patients with primary infections with DENV-1 than in patient infected with DENV-2 (P < 0.0001) and in patients with primary infections with DENV-2 than in patients with secondary infections with DENV-2 (P = 0.0051). Unexpectedly, viremia levels were higher in patients with DF than in those with DHF infected with either DENV-1 or DENV-2 (P = 0.0019 and P = 0.001, respectively) and in patients with primary infections than those with secondary DENV-2 infections (P < 0.0001). Results indicate that levels of circulating NS1 vary according to the infecting serotype, immunologic status (primary or secondary infection), and dengue disease severity.
引用
收藏
页码：446 / 454
页数：9
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