ARN COVID-19 COMIRNATY Vaccine desensitization in a case of PEG Severe Immediate Hypersensitivity

被引：2

作者：

Huynh, V. A. ^{[1
]}

Janssen, C. ^{[2
]}

Beaumier, L. ^{[3
]}

机构：

[1] Ctr Hosp Annecy Genevois, Serv Allergol, 1 Ave Hop, F-74370 Epagny Metz Tessy, France

[2] Ctr Hosp Annecy Genevois, Serv Infectiol, 1 Ave Hop, F-74370 Epagny Metz Tessy, France

[3] Ctr Hosp Annecy Genevois, Pharm, 1 Ave Hop, F-74370 Epagny Metz Tessy, France

来源：

REVUE FRANCAISE D ALLERGOLOGIE | 2022年 / 62卷 / 04期

关键词：

Allergy; Anaphylaxis; Hypersensitivity; Covid-19; vaccines; Desensitization; Polyethylene glycol (PEG); Skin test; mRNA vaccine;

D O I：

10.1016/j.reval.2021.07.007

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

Vaccination is the most efficient way to fight the Covid epidemic. However, suspicion of severe hypersensitivity to PEG (PolyEthylen Glycol) usually constitutes a vaccine contraindication. We report the case of a patient with a proven allergy to PEG and skin sensitization to the COMIRNATY vaccine (PEG in its composition). He was able to benefit from the vaccine under the 5-step desensitization protocol. Conclusions: Specific allergological management should be offered to patients suspected of severe hypersensitivity to PEG and other vaccine excipients. We propose a solution for Comirnaty administration for patients with a proven severe allergy to PEG. ?? 2021 Elsevier Masson SAS. All rights reserved.

引用

页码：431 / 434

页数：4

共 17 条

[1]

[Anonymous], 2021, ACT POINT SIT SURV V

[2]

[Anonymous], 2021, VACC COM PFIZ BIONTE

[3]

[Anonymous], ACTUALITE POINT SITU

[4] mRNA Vaccines to Prevent COVID-19 Disease and Reported Allergic Reactions: Current Evidence and Suggested Approach [J].

Banerji, Aleena ;

Wickner, Paige G. ;

Saff, Rebecca ;

Stone, Cosby A. ;

Robinson, Lacey B. ;

Long, Aidan A. ;

Wolfson, Anna R. ;

Williams, Paul ;

Khan, David A. ;

Phillips, Elizabeth ;

Blumenthal, Kimberly G. .

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE, 2021, 9 (04) :1423-1437

[5] Clinical manifestations and impact on daily life of allergy to polyethylene glycol (PEG) in ten patients [J].

Bruusgaard-Mouritsen, Maria A. ;

Johansen, Jeanne D. ;

Garvey, Lene H. .

CLINICAL AND EXPERIMENTAL ALLERGY, 2021, 51 (03) :463-470

[6] A New Era for Drug Desensitizations [J].

Castells, Mariana C. .

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE, 2015, 3 (04) :639-640

[7] A 12-steps desensitization protocol for pediatric patients with hypersensitivity to pegylated asparaginase [J].

Concha, S. ;

Barriga, F. ;

Ovalle, P. ;

Hoyos-Bachiloglu, R. .

ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY, 2020, 124 (02) :208-210

[8]

Karine P, 2021, STRATEGIE VACCINATIO, P20

[9] Adverse reactions to vaccines practice parameter 2012 update [J].

Kelso, John M. ;

Greenhawt, Matthew J. ;

Li, James T. ;

Nicklas, Richard A. ;

Bernstein, David I. ;

Blessing-Moore, Joann ;

Cox, Linda ;

Khan, David ;

Lang, David M. ;

Oppenheimer, John ;

Portnoy, Jay M. ;

Randolph, Christopher R. ;

Schuller, Diane E. ;

Spector, Sheldon L. ;

Tilles, Stephen A. ;

Wallace, Dana .

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2012, 130 (01) :25-43

[10] Administration of a Second Dose of the Moderna COVID-19 Vaccine After an Immediate Hypersensitivity Reaction With the First Dose: Two Case Reports [J].

Mustafa, S. Shahzad ;

Ramsey, Allison ;

Staicu, Mary L. .

ANNALS OF INTERNAL MEDICINE, 2021, 174 (08) :1177-+

← 1 2 →