New phenstatin-fatty acid conjugates: Synthesis and evaluation

被引：9
作者：
Chen, Jinhui [1 ]
Brown, David P. [1 ]
Wang, Yi-Jun [2 ]
Chen, Zhe-Sheng [2 ]
机构：
[1] St Johns Univ, Dept Chem, Jamaica, NY 11439 USA
[2] St Johns Univ, Dept Pharmaceut Sci, Jamaica, NY 11439 USA
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2013年 / 23卷 / 18期
关键词：
Conjugates; Fatty acids; Microtubule-binding drugs; Cancer chemotherapy; Drug resistance reversal; HYBRIDS; AGENTS;
D O I：
10.1016/j.bmcl.2013.07.025
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
New phenstatin-fatty acid conjugates have been synthesized and tested against the KB-3-1, H460, MCF-7 and HEK293 cell lines, with an increase in anti-proliferative activity being observed at the micro-molar level paralleling an increase in un-saturation in the fatty acid component. (C) 2013 Elsevier Ltd. All rights reserved.
引用
收藏
页码：5119 / 5122
页数：4
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