DNA replication stress and cancer chemotherapy

被引：83

作者：

Kitao, Hiroyuki ^{[1
]}

Iimori, Makoto ^{[1
]}

Kataoka, Yuki ^{[1
,2
]}

Wakasa, Takeshi ^{[2
,3
]}

Tokunaga, Eriko ^{[4
]}

Saeki, Hiroshi ^{[3
]}

Oki, Eiji ^{[3
]}

Maehara, Yoshihiko ^{[3
]}

机构：

[1] Kyushu Univ, Dept Mol Canc Biol, Grad Sch Pharmaceut Sci, Fukuoka, Japan

[2] Taiho Pharmaceut Co Ltd, Tokushima, Ibaraki, Japan

[3] Kyushu Univ, Dept Surg & Sci, Grad Sch Med Sci, Fukuoka, Japan

[4] Kyushu Canc Ctr, Dept Breast Oncol, Natl Hosp Org, Fukuoka, Japan

来源：

CANCER SCIENCE | 2018年 / 109卷 / 02期

关键词：

chemotherapeutic drugs; DNA damage response; DNA replication stress; genome instability; tumorigenesis; DAMAGE CHECKPOINT; TRANSCRIPTIONAL REPRESSION; COMBINATION ANTIMETABOLITE; GENOMIC INSTABILITY; ANTITUMOR-ACTIVITY; ATR; PHOSPHORYLATION; OXALIPLATIN; CHK1; ACTIVATION;

D O I：

10.1111/cas.13455

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

DNA replication is one of the fundamental biological processes in which dysregulation can cause genome instability. This instability is one of the hallmarks of cancer and confers genetic diversity during tumorigenesis. Numerous experimental and clinical studies have indicated that most tumors have experienced and overcome the stresses caused by the perturbation of DNA replication, which is also referred to as DNA replication stress (DRS). When we consider therapeutic approaches for tumors, it is important to exploit the differences in DRS between tumor and normal cells. In this review, we introduce the current understanding of DRS in tumors and discuss the underlying mechanism of cancer therapy from the aspect of DRS.

引用

页码：264 / 271

页数：8

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