New polyhydroxylated steroids from the marine pulmonate Trimusculus peruvianus

被引：9

作者：

Díaz-Marrero, AR

Dorta, E

Cueto, M

Rovirosa, J

San-Martín, A

Loyola, A

Darias, J ^{[1
]}

机构：

[1] CSIC, Inst Prod Nat & Agrobiol, Avda Astrofis F Sanchez 3,Apdo 195, Tenerife 38206, Spain

[2] Univ Chile, Fac Ciencias, Dept Quim, Santiago, Chile

[3] Univ Antofagasta, Fac Ciencias, Dept Quim, Antofagasta, Chile

来源：

ARKIVOC | 2003年

关键词：

marine mollusk; Trimusculus peruvianus; Delta(5)- and Delta(7)-polyhydroxylated steroids; cytotoxic activity;

D O I：

10.3998/ark.5550190.0004.a12

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Two new sterols, 1-2, unusually hydroxylated at C-21 have been isolated from the marine pulmonate Trimusculus peruvianus. Compound 2 possesses a Delta(7)-3alpha, 5alpha, 6beta-triol nucleus unprecedented in marine organisms. The structure and stereochemistries were determined on the basis of spectral studies, particularly NMR and MS spectroscopic data. 1 and 2 are the entire sterol content of the mollusk and both exhibit moderate in vitro cytotoxic activity against human colon carcinoma cell lines.

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收藏

页码：107 / 117

页数：11

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