Lipid exchange between membranes: effects of temperature and ionic strength

被引：0
|
作者：
Jiang Zhong-Ying [1 ,2 ]
Zhang Guo-Liang [1 ]
Ma Jing [1 ]
Zhu Tao [2 ]
机构：
[1] Yili Normal Univ, Sch Elect & Informat, Yining 835000, Peoples R China
[2] Nanjing Univ, Coll Phys, Nanjing 210093, Jiangsu, Peoples R China
来源：
ACTA PHYSICA SINICA | 2013年 / 62卷 / 01期
基金：
中国国家自然科学基金;
关键词：
transmembrane lipid exchange; temperature; ionic strength; intermembrane contact area; OPPOSITELY CHARGED VESICLES; SUPPORTED MEMBRANES; SURFACE-CHARGE; QCM-D; BILAYER; FUSION; DELIVERY; SIZE;
D O I：
10.7498/aps.62.01870
中图分类号：
O4 [物理学];
学科分类号：
0702 ;
摘要：
Transmembrane lipid exchange is critical to membrane function and pharmaceutical application. The exchange process is not fully understood and it is explored by quartz crystal microbalance with dissipation monitor method in this paper. It is found that the vesicle deformation discrepancy is not significant for the supported-lipid-bilayer-attached vesicles under different thermal and ionic strength conditions. And hence the total intermembrane contact area is determined by the vesicle adsorption amount. The maximum total intermembrane contact area decreases with the increase of temperature and the decrease of ionic strength. The changes of the vesicle adsorption rate and the transmembrane lipid exchange rate induced by temperature and ionic strength are elucidated to understand the observation above. The study helps explain some physiological phenomena and provides some guidelines for drug delivery researches.
引用
收藏
页数：7
相关论文
共 24 条
  • [1] Fabrication and characterization of human serum albumin and L-α-dimyristoylphosphatidic acid microcapsules based on template technique
    An, ZH
    Tao, C
    Lu, G
    Möhwald, H
    Zheng, SP
    Cui, Y
    Li, JB
    [J]. CHEMISTRY OF MATERIALS, 2005, 17 (10) : 2514 - 2519
  • [2] Designing Nanoparticle Translocation through Membranes by Computer Simulations
    Ding, Hong-ming
    Tian, Wen-de
    Ma, Yu-qiang
    [J]. ACS NANO, 2012, 6 (02) : 1230 - 1238
  • [3] Lipid traffic: Floppy drives and a superhighway
    Holthuis, JCM
    Levine, TP
    [J]. NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2005, 6 (03) : 209 - 220
  • [4] SPONTANEOUS PHOSPHATIDYLCHOLINE TRANSFER BY COLLISION BETWEEN VESICLES AT HIGH LIPID-CONCENTRATION
    JONES, JD
    THOMPSON, TE
    [J]. BIOCHEMISTRY, 1989, 28 (01) : 129 - 134
  • [5] Formation of supported membranes from vesicles
    Keller, CA
    Glasmästar, K
    Zhdanov, VP
    Kasemo, B
    [J]. PHYSICAL REVIEW LETTERS, 2000, 84 (23) : 5443 - 5446
  • [6] Lipid bilayer vesicle fusion: Intermediates captured by high-speed microfluorescence spectroscopy
    Lei, GH
    MacDonald, RC
    [J]. BIOPHYSICAL JOURNAL, 2003, 85 (03) : 1585 - 1599
  • [7] Li JB, 2001, ANGEW CHEM INT EDIT, V40, P891, DOI 10.1002/1521-3773(20010302)40:5<891::AID-ANIE891>3.0.CO
  • [8] 2-K
  • [9] Electrostatically Mediated Liposome Fusion and Lipid Exchange with a Nanoparticle-Supported Bilayer for Control of Surface Charge, Drug Containment, and Delivery
    Liu, Juewen
    Jiang, Xingmao
    Ashley, Carlee
    Brinker, C. Jeffrey
    [J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2009, 131 (22) : 7567 - +
  • [10] Interaction, lipid exchange, and effect of vesicle size in systems of oppositely charged vesicles
    MarchiArtzner, V
    Jullien, L
    Belloni, L
    Raison, D
    Lacombe, L
    Lehn, JM
    [J]. JOURNAL OF PHYSICAL CHEMISTRY, 1996, 100 (32): : 13844 - 13856
123