Outcomes of 48 patients with primary angioimmunoblastic T-cell lymphoma in real-world clinical practice: a single-center experience

被引:0
作者
Huang, Chen [1 ]
Zhang, Huichao [2 ]
Zhao, Guimin [1 ]
Ma, Guangyu [1 ]
Wu, Xiaolin [1 ]
Gao, Yuhuan [1 ]
Diao, Lanping [1 ]
Liu, Lihong [1 ]
机构
[1] Hebei Med Univ, Hosp 4, Dept Hematol, Shijiazhuang 050011, Hebei, Peoples R China
[2] Hebei Med Univ, Hosp 4, Dept Clin Lab, Shijiazhuang 050011, Hebei, Peoples R China
来源
INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE | 2019年 / 12卷 / 01期
关键词
Angioimmunoblastic T-cell lymphoma; efficacy; survival analysis; adverse events; ENDOTHELIAL GROWTH-FACTOR; PROGNOSTIC-FACTORS; PHASE-II; THP-COP; THALIDOMIDE; MULTICENTER; CHOP; EXPRESSION; FEATURES; TRIAL;
D O I
暂无
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
Angioimmunoblastic T-cell lymphoma (AITL) is a rare cancer of the lymphatic system. There is no effective chemotherapy regimen for long-term survival. The traditional chemotherapy regimen consists of cyclophosphamide, doxorubicin, vincristine, and prednisolone (CHOP). This study evaluated the outcomes of a cyclophosphamide, doxorubicin, vincristine, prednisolone, and thalidomide (CHOP-T) regimen for patients with primary AITL. Clinical data of 48 primary AITL patients treated with CHOP-T or CHOP regimens were retrospectively analyzed. The 2-year overall survival (OS) and progression-free survival (PFS) rates of all patients were 52.8% and 36.6%, respectively. The 2-year OS rates of the CHOP-T group were better than that of the CHOP group (70.6% vs. 44.6%, P=0.045). However, this did not translate into significantly better PFS (P=0.122) or complete remission (CR) rates (P=0.068). Multiple-factor analysis showed that positive Coombs tests and bone marrow infiltration were independent prognostic factors of PFS. Only a positive Coombs test tended to be associated with lower OS rates. There were no statistically significant differences in hematologic toxicity between the two groups (P=0.299). Non-hematological toxicity in the CHOP-T group, such as diarrhea, peripheral neuropathy, and somnolence/fatigue, was significantly higher than in the CHOP group (P=0.017). The present study showed that the CHOP-T regimen was more effective than the CHOP regimen in improving OS and CR rates, but non-hematological toxicities were higher. Severity of diarrhea, peripheral neuropathy, and somnolence/fatigue was significantly associated with thalidomide and no efficient precautions were observed.
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页码:861 / 872
页数:12
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