Electrochemical Impedance Spectroscopy Based Biosensors: Mechanistic Principles, Analytical Examples and Challenges towards Commercialization for Assays of Protein Cancer Biomarkers

被引：139

作者：

Bertok, Tomas ^{[1
]}

Lorencova, Lenka ^{[1
]}

Chocholova, Erika ^{[1
]}

Jane, Eduard ^{[1
]}

Vikartovska, Alica ^{[1
]}

Kasak, Peter ^{[2
]}

Tkac, Jan ^{[1
]}

机构：

[1] Slovak Acad Sci, Inst Chem, Dept Glycobiotechnol, Dubravska Cesta 9, Bratislava 84538, Slovakia

[2] Qatar Univ, Ctr Adv Mat, Doha 2713, Qatar

来源：

CHEMELECTROCHEM | 2019年 / 6卷 / 04期

基金：

欧洲研究理事会;

关键词：

Biosensor; cancer; clinical diagnostics; electrochemical impedance spectroscopy; oncomarkers; LABEL-FREE DETECTION; SENSITIVE IMPEDIMETRIC IMMUNOSENSOR; GROWTH-FACTOR RECEPTOR; INTERDIGITATED ELECTRODE; LECTIN BIOSENSORS; ALPHA-FETOPROTEIN; ANALYTICAL-MODEL; PROSTATE-CANCER; SENSORS; EIS;

D O I：

10.1002/celc.201800848

中图分类号：

O646 [电化学、电解、磁化学];

学科分类号：

081704 ;

摘要：

Impedimetric affinity biosensors are, without any doubt, among the most sensitive analytical devices available, offering low limits of detection and wide linear response ranges. There are, however, only a few papers detailing the application of impedimetric biosensors for the analysis of clinically relevant samples with due clinical performance. The fact that these devices have not found their way to any commercial or clinical use to date might be surprising, since an electrochemical assay platform based on portable potentiostats is a success story for monitoring a range of clinical parameters such as ions, haematological indicators and glucose. This review discusses the reasons behind this discrepancy and addresses the barriers to be overcome in order to achieve the point-of-care diagnostics using such devices for detection of protein oncomarkers approved by FDA. The final part of the review covers the most recent progress in the area.

引用

页码：989 / 1003

页数：15

共 138 条

[1]

Al-Musalhi Khawla, 2015, Oman Med J, V30, P428, DOI 10.5001/omj.2015.85

[2]

[Anonymous], 2012, Impedance Spectroscopy, P163, DOI DOI 10.1002/9781118164075.CH8

[3] An impedimetric response study for the efficient detection of breast cancer specific biomarker CA 15-3 using a tin oxide thin film based immunoelectrode [J].