Far beyond the motor neuron: the role of glial cells in amyotrophic lateral sclerosis

被引：1

作者：

Sgobbi de Souza, Paulo Victor ^{[1
]}

Vieira de Rezende Pinto, Wladimir Bocca ^{[1
]}

Rezende Filho, Flavio Moura ^{[1
]}

Bulle Oliveira, Acary Souza ^{[1
]}

机构：

[1] Univ Fed Sao Paulo, Dept Neurol & Neurocirurgia, Sao Paulo, SP, Brazil

来源：

ARQUIVOS DE NEURO-PSIQUIATRIA | 2016年 / 74卷 / 10期

关键词：

motor neurons; astrocyte; microglia; amyotrophic lateral sclerosis; motor neuron disease; DISEASE; MICROGLIA; TARGET; ALS; NEUROINFLAMMATION; DYSFUNCTION; ASTROCYTES; MECHANISMS; PATHWAYS; DEATH;

D O I：

10.1590/0004-282X20160117

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Motor neuron disease is one of the major groups of neurodegenerative diseases, mainly represented by amyotrophic lateral sclerosis. Despite wide genetic and biochemical data regarding its pathophysiological mechanisms, motor neuron disease develops under a complex network of mechanisms not restricted to the unique functions of the alpha motor neurons but which actually involve diverse functions of glial cell interaction. This review aims to expose some of the leading roles of glial cells in the physiological mechanisms of neuron-glial cell interactions and the mechanisms related to motor neuron survival linked to glial cell functions.

引用

页码：849 / 854

页数：6

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