Safe CRISPR: Challenges and Possible Solutions

被引：48

作者：

Pineda, Michael ^{[1
]}

Lear, Ashley ^{[1
]}

Collins, James P. ^{[2
]}

Kiani, Samira ^{[1
,3
]}

机构：

[1] Arizona State Univ, Sch Biol & Hlth Syst Engn, Tempe, AZ 85287 USA

[2] Arizona State Univ, Sch Life Sci, Tempe, AZ 85287 USA

[3] Www Kianilab Com, Tempe, AZ 85281 USA

来源：

TRENDS IN BIOTECHNOLOGY | 2019年 / 37卷 / 04期

关键词：

GENE-DRIVE; SELFISH GENES; SYSTEM; DELIVERY; VECTOR; NANOPARTICLES; TECHNOLOGIES; SPECIFICITY; NUCLEASES; EVOLUTION;

D O I：

10.1016/j.tibtech.2018.09.010

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Applications of CRISPR in human health and in gene drives are at the forefront of biological research as tools. This technology will affect humankind and our environment, so as this technology pushes forward, the design and implementation of safety measures is imperative. Novel technologies and forethought in various applications of CRISPR are essential for using this technology safely. Here, we review environmental and health-related safety concerns associated with using CRISPR and ways proposed to minimize risk.

引用

页码：389 / 401

页数：13

共 98 条

[41] The creation and selection of mutations resistant to a gene drive over multiple generations in the malaria mosquito [J].

Hammond, Andrew M. ;

Kyrou, Kyros ;

Bruttini, Marco ;

North, Ace ;

Galizi, Roberto ;

Karlsson, Xenia ;

Kranjc, Nace ;

Carpi, Francesco M. ;

D'Aurizio, Romina ;

Crisanti, Andrea ;

Nolan, Tony .

PLOS GENETICS, 2017, 13 (10)

[42] Anti-CRISPR proteins encoded by archaeal lytic viruses inhibit subtype I-D immunity [J].

He, Fei ;

Bhoobalan-Chitty, Yuvaraj ;

Van, Lan B. ;

Kjeldsen, Anders L. ;

Dedola, Matteo ;

Makarova, Kira S. ;

Koonin, Eugene V. ;

Brodersen, Ditlev E. ;

Peng, Xu .

NATURE MICROBIOLOGY, 2018, 3 (04) :461-469

[43] One small edit for humans, one giant edit for humankind? Points and questions to consider for a responsible way forward for gene editing in humans [J].

Howard, Heidi C. ;

van El Carla, G. ;

Forzano, Francesca ;

Radojkovic, Dragica ;

Rial-Sebbag, Emmanuelle ;

de Wert, Guido ;

Borry, Pascal ;

Cornel, Martina C. .

EUROPEAN JOURNAL OF HUMAN GENETICS, 2018, 26 (01) :1-11

[44] p53 inhibits CRISPR-Cas9 engineering in human pluripotent stem cells [J].

Ihry, Robert J. ;

Worringer, Kathleen A. ;

Salick, Max R. ;

Frias, Elizabeth ;

Ho, Daniel ;

Theriault, Kraig ;

Kommineni, Sravya ;

Chen, Julie ;

Sondey, Marie ;

Ye, Chaoyang ;

Randhawa, Ranjit ;

Kulkarni, Tripti ;

Yang, Zinger ;

McAllister, Gregory ;

Russ, Carsten ;

Reece-Hoyes, John ;

Forrester, William ;

Hoffman, Gregory R. ;

Dolmetsch, Ricardo ;

Kaykas, Ajamete .

NATURE MEDICINE, 2018, 24 (07) :939-+

[45] Engineering Synthetic Gene Circuits in Living Cells with CRISPR Technology [J].

Jusiak, Barbara ;

Cleto, Sara ;

Perez-Pinera, Pablo ;

Lu, Timothy K. .

TRENDS IN BIOTECHNOLOGY, 2016, 34 (07) :535-547

[46] Introducing precise genetic modifications into human 3PN embryos by CRISPR/Cas-mediated genome editing [J].

Kang, Xiangjin ;

He, Wenyin ;

Huang, Yuling ;

Yu, Qian ;

Chen, Yaoyong ;

Gao, Xingcheng ;

Sun, Xiaofang ;

Fan, Yong .

JOURNAL OF ASSISTED REPRODUCTION AND GENETICS, 2016, 33 (05) :581-588

[47]

Kiani S, 2015, NAT METHODS, V12, P1051, DOI [10.1038/NMETH.3580, 10.1038/nmeth.3580]

[48]

Kiani S, 2014, NAT METHODS, V11, P723, DOI [10.1038/NMETH.2969, 10.1038/nmeth.2969]

[49] RNA-targeting CRISPR comes of age [J].

Kim, V. Narry .

NATURE BIOTECHNOLOGY, 2018, 36 (01) :44-45

[50]

Kingdom U, 2016, NATURE, V534, P8

← 1 2 3 4 5 6 7 8 9 10 →