Safe CRISPR: Challenges and Possible Solutions

被引：48

作者：

Pineda, Michael ^{[1
]}

Lear, Ashley ^{[1
]}

Collins, James P. ^{[2
]}

Kiani, Samira ^{[1
,3
]}

机构：

[1] Arizona State Univ, Sch Biol & Hlth Syst Engn, Tempe, AZ 85287 USA

[2] Arizona State Univ, Sch Life Sci, Tempe, AZ 85287 USA

[3] Www Kianilab Com, Tempe, AZ 85281 USA

来源：

TRENDS IN BIOTECHNOLOGY | 2019年 / 37卷 / 04期

关键词：

GENE-DRIVE; SELFISH GENES; SYSTEM; DELIVERY; VECTOR; NANOPARTICLES; TECHNOLOGIES; SPECIFICITY; NUCLEASES; EVOLUTION;

D O I：

10.1016/j.tibtech.2018.09.010

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Applications of CRISPR in human health and in gene drives are at the forefront of biological research as tools. This technology will affect humankind and our environment, so as this technology pushes forward, the design and implementation of safety measures is imperative. Novel technologies and forethought in various applications of CRISPR are essential for using this technology safely. Here, we review environmental and health-related safety concerns associated with using CRISPR and ways proposed to minimize risk.

引用

页码：389 / 401

页数：13

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