Localization of V1a vasopressin receptor mRNA expression in cultured neurons, astroglia, and oligodendroglia of rat cerebral cortex

被引：18

作者：

Yamazaki, RS

Chen, Q

Schreiber, SS

Brinton, RD

机构：

[1] UNIV SO CALIF,PHARMACEUT SCI CTR,DEPT MOL PHARMACOL & TOXICOL,LOS ANGELES,CA 90033

[2] UNIV SO CALIF,SCH MED,DEPT NEUROL,LOS ANGELES,CA 90033

来源：

MOLECULAR BRAIN RESEARCH | 1997年 / 45卷 / 01期

基金：

美国国家科学基金会;

关键词：

vasopressin receptor; RT-PCR; neuron; astroglia; oligodendroglia; mRNA; cerebral cortex; learning and memory;

D O I：

10.1016/S0169-328X(96)00285-9

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Previous studies suggested the existence of V1a vasopressin receptors (V1aR) in the cerebral cortex. Here, we investigated the cellular and regional localization of V1aR in the E18 rat cerebral cortex using RT-PCR and Southern blot analysis of V1aR mRNA derived from enriched cultures of neurons, astroglia, and oligodendroglia from four cortical regions (rostral, caudal, dorsal and ventral). V1aR mRNA was detected in each of the cell types within each of the regions studied. These data indicate that V1aR is broadly distributed throughout the cerebral cortex and suggest that vasopressin plays an important role in cortical functions.

引用

页码：138 / 140

页数：3

共 23 条

[1] VASOPRESSIN-INDUCED NEUROTROPHISM IN CULTURED HIPPOCAMPAL-NEURONS VIA V-1 RECEPTOR ACTIVATION [J].