Response to a Single Dose of Sildenafil in Single-Ventricle Patients: An Echocardiographic Evaluation

被引：7

作者：

Jackson, Kimberly W. ^{[1
]}

Butts, Ryan J. ^{[1
]}

Svenson, Amy J. ^{[1
]}

McQuinn, Tim C. ^{[1
]}

Atz, Andrew M. ^{[1
]}

机构：

[1] Med Univ S Carolina, Dept Pediat, Div Cardiol, Charleston, SC 29425 USA

来源：

PEDIATRIC CARDIOLOGY | 2013年 / 34卷 / 07期

关键词：

Congenital heart disease; Fontan; Pediatric; Univentricular heart; EXERCISE;

D O I：

10.1007/s00246-012-0415-4

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

New evidence of increased phosphodiesterase-5 (PDE-5) in hypertrophied human myocardium suggests that sildenafil, a selective PDE-5 inhibitor, may improve muscle contraction and therefore improve ventricular function. The purpose of this study was to compare ventricular function as assessed by echocardiography in 10 surgically palliated single-ventricle patients at baseline and again after a single dose of sildenafil. The velocity time integral of the ventricular outflow tract was increased 2 h after sildenafil administration (p = 0.01), thus suggesting an improvement in cardiac output.

引用

页码：1739 / 1742

页数：4

共 9 条

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