Focus on PTEN regulation

被引：114
作者：
Brito, Miriam Bermudez [1 ]
Goulielmaki, Evangelia [1 ]
Papakonstanti, Evangelia A. [1 ]
机构：
[1] Univ Crete, Sch Med, Dept Biochem, GR-71003 Iraklion, Greece
来源：
FRONTIERS IN ONCOLOGY | 2015年 / 5卷
关键词：
PTEN; transcription; translation; protein interactions; localization; TUMOR-SUPPRESSOR PTEN; PROTEIN-TYROSINE PHOSPHATASES; COMPETING ENDOGENOUS RNAS; UBIQUITIN LIGASE NEDD4-1; TENSIN-HOMOLOG PTEN; GROWTH-FACTOR-BETA; LUNG-CANCER CELLS; COLORECTAL-CANCER; BREAST-CANCER; UP-REGULATION;
D O I：
10.3389/fonc.2015.00166
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The role of phosphatase and tensin homolog on chromosome 10 (PTEN) as a tumor suppressor has been for a long time attributed to its lipid phosphatase activity against PI(3,4,5)P-3, the phospholipid product of the class I PI3Ks. Besides its traditional role as a lipid phosphatase at the plasma membrane, a wealth of data has shown that PTEN can function independently of its phosphatase activity and that PTEN also exists and plays a role in the nucleus, in cytoplasmic organelles, and extracellularly. Accumulating evidence has shed light on diverse physiological functions of PTEN, which are accompanied by a complex regulation of its expression and activity. PTEN levels and function are regulated transcriptionally, post transcriptionally, and post-translationally. PTEN is also sensitive to regulation by its interacting proteins and its localization. Herein, we summarize the current knowledge on mechanisms that regulate the expression and enzymatic activity of PTEN and its role in human diseases.
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页数：15
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