Towards harmonization of microscopy methods for malaria clinical research studies

被引：15

作者：

Dhorda, Mehul ^{[1
,2
,3
]}

Ba, El Hadji ^{[4
]}

Baird, J. Kevin ^{[2
,5
]}

Barnwell, John ^{[6
]}

Bell, David

Carter, Jane Y. ^{[7
]}

Dondorp, Arjen ^{[2
,3
]}

Ekawati, Lenny ^{[5
]}

Gatton, Michelle ^{[8
]}

Gonzalez, Iveth ^{[9
]}

Guerin, Philippe J. ^{[2
,10
]}

Incardona, Sandra ^{[11
]}

Lilley, Ken ^{[12
]}

Menard, Didier ^{[13
]}

Nosten, Francois ^{[3
,14
]}

Obare, Peter ^{[15
]}

Ogutu, Bernhards ^{[15
]}

Olliaro, Piero L. ^{[2
]}

Price, Ric N. ^{[2
,3
,10
,16
,17
]}

Proux, Stephane ^{[3
,14
]}

Ramsay, Andrew R. ^{[18
]}

Reeder, John C. ^{[19
,20
]}

Silamut, Kamolrat ^{[3
]}

Sokhna, Cheikh ^{[4
]}

机构：

[1] WorldWide Antimalarial Resistance Network, 60th Anniversary Chalermprakhiat Bldg,3rd Floor, Bangkok 10400, Thailand

[2] Univ Oxford, Nuffield Dept Med, Ctr Trop Med & Global Hlth, Oxford, England

[3] Mahidol Univ, Fac Trop Med, Mahidol Oxford Trop Med Res Unit, Bangkok, Thailand

[4] UMR 257 IRD VITROME, Campus IRD UCAD, Dakar, Senegal

[5] Eijkman Oxford Clin Res Unit, Jakarta, Indonesia

[6] US Ctr Dis Control & Prevent, Atlanta, GA USA

[7] Amref Hlth Africa Headquarters, Nairobi, Kenya

[8] Queensland Univ Technol, Brisbane, Qld, Australia

[9] Terre Hommes Fdn, Geneva, Switzerland

[10] WorldWide Antimalarial Resistance Network, Oxford, England

[11] FIND, Geneva, Switzerland

[12] Australian Def Force Malaria & Infect Dis Inst, Enoggera, Australia

[13] Inst Pasteur Cambodge, Phnom Penh, Cambodia

[14] Shoklo Malaria Res Unit, Mae Sot, Thailand

[15] Kenya Govt Med Res Ctr, Kisumu, Kenya

[16] Menzies Sch Hlth Res, Global Hlth Div, Darwin, NT, Australia

[17] Charles Darwin Univ, Darwin, NT, Australia

[18] Univ St Andrews, Sch Med, St Andrews, Fife, Scotland

[19] World Bank, UNDP, Cosponsored Programme UNICEF, Special Programme Res & Training Trop Dis TDR, Geneva, Switzerland

[20] WHO, Geneva, Switzerland

来源：

MALARIA JOURNAL | 2020年 / 19卷 / 01期

基金：

英国惠康基金;

关键词：

Malaria; Microscopy; Harmonization; Clinical research; Diagnostic; Standard; DENSITY; THICK;

D O I：

10.1186/s12936-020-03352-z

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Microscopy performed on stained films of peripheral blood for detection, identification and quantification of malaria parasites is an essential reference standard for clinical trials of drugs, vaccines and diagnostic tests for malaria. The value of data from such research is greatly enhanced if this reference standard is consistent across time and geography. Adherence to common standards and practices is a prerequisite to achieve this. The rationale for proposed research standards and procedures for the preparation, staining and microscopic examination of blood films for malaria parasites is presented here with the aim of improving the consistency and reliability of malaria microscopy performed in such studies. These standards constitute the core of a quality management system for clinical research studies employing microscopy as a reference standard. They can be used as the basis for the design of training and proficiency testing programmes as well as for procedures and quality assurance of malaria microscopy in clinical research.

引用

页数：14

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