Phytochemical profile of three Ballota species essential oils and evaluation of the effects on human cancer cells

被引：15

作者：

Rigano, Daniela ^{[1
]}

Marrelli, Mariangela ^{[2
]}

Formisano, Carmen ^{[1
]}

Menichini, Francesco ^{[2
]}

Senatore, Felice ^{[1
]}

Bruno, Maurizio ^{[3
]}

Conforti, Filomena ^{[2
]}

机构：

[1] Univ Naples Federico II, Dept Pharm, Naples, Italy

[2] Univ Calabria, Dept Pharm Hlth & Nutr Sci, Arcavacata Di Rende, CS, Italy

[3] Univ Palermo, Dept Biol Chem & Pharmaceut Technol & Sci STEBICE, Palermo, Italy

来源：

NATURAL PRODUCT RESEARCH | 2017年 / 31卷 / 04期

关键词：

Ballota species; essential oil; antiproliferative activity; sesquiterpenes; hepatoma; breast cancer; NIGRA SSP FOETIDA; ANTIMICROBIAL ACTIVITY; L; PHENYLPROPANOIDS; SAXATILIS; TURKEY; PLANTS;

D O I：

10.1080/14786419.2016.1185722

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Three Ballota species, Ballota undulata, Ballota saxatilis and Ballota nigra ssp. foetida, were investigated for their cytotoxicity against two human cancer cells, hepatoma HepG2 cell line and breast cancer MCF-7 cell line, and for their antioxidant activity. The chemical composition of essential oils was studied by GC and GC-MS. Sesquiterpenes were the main constituents. The most antiproliferative essential oil against HepG2 cells was B. undulata with a percentage of inhibition of 81.36 +/- 3.54 at a concentration of 100 mu g/mL, while against MCF-7 cells essential oil from B. saxatilis was the most active with a percentage of inhibition of 24.18 +/- 1.13 at a concentration of 100 mu g/mL. The antioxidant activity was investigated by DPPH test for all the oils. B. undulata showed the highest antiradical effect, with IC50 value of 529.7 +/- 37.4 mu g/mL. [GRAPHICS] .

引用

页码：436 / 444

页数：9

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