Genome interrupted: sequencing of prostate cancer reveals the importance of chromosomal rearrangements

被引：9
|
作者：
Kumar, Akash [1 ]
Shendure, Jay [1 ]
Nelson, Peter S. [2 ]
机构：
[1] Univ Washington, Dept Genome Sci, Seattle, WA 98105 USA
[2] Fred Hutchinson Canc Res Ctr, Seattle, WA 98109 USA
来源：
GENOME MEDICINE | 2011年 / 3卷
关键词：
Prostate Cancer; Prostate Cancer Cell Line; Open Chromatin; Primary Prostate Cancer; Prostate Cancer Research;
D O I：
10.1186/gm237
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
A recent study involving whole genome sequencing of seven prostate cancers has provided the first comprehensive assessment of genomic changes that underlie this common malignancy. Point mutations were found to be infrequent but changes in chromosome structure were common. Rearrangements were linked to chromatin organization and associated with regions involved in transcription factor binding. Novel candidate prostate cancer genes were also identified, highlighting the importance of genome sequencing to identify oncogenic changes that are otherwise invisible to detection.
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页数：4
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