Synthesis of Some 5-[2-Aryl-2-oxoethyl]-1,3-dimethylpyrimidine-2,4,6-trione Derivatives by a One-pot, Three-component Reaction

被引：4

作者：

Khalafy, Jabbar ^{[1
]}

Ezzati, Mahnaz ^{[1
]}

Madadi, Parinaz ^{[1
]}

Marjani, Ahmad Poursattar ^{[1
]}

Asl, Hooman Yaghoobnejad ^{[2
]}

机构：

[1] Urmia Univ, Dept Organ Chem, Fac Chem, Orumiyeh, Iran

[2] Missouri Univ Sci & Technol, Dept Chem, Rolla, MO 65409 USA

来源：

SOUTH AFRICAN JOURNAL OF CHEMISTRY-SUID-AFRIKAANSE TYDSKRIF VIR CHEMIE | 2017年 / 70卷

关键词：

Arylglyoxals; L-cysteine; 1,3-dimethylbarbituric acid; phosphotungstic acid; one-pot; multi-component reaction; BARBITURIC-ACID DERIVATIVES; ANTICANCER ACTIVITY; WATER; OXIDATION; CONVENIENT; RADICALS; ANALOGS; AMINES;

D O I：

10.17159/0379-4350/2017/v70a19

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

This study reports the reduction of a, a-unsaturated ketones 4a-g, formed by condensation of arylglyoxals 2a-g with 1,3-dimethylbarbituric acid (3) by L-cysteine (5) in the presence of phosphotungstic acid as a catalyst. This reaction leads to the formation of 5-[2-aryl-2-oxoethyl]-1,3-dimethylpyrimidine-2,4,6-triones 6a-g, with no sign of any heterocyclic product formation. The structure of compound 6f was confirmed by X-ray crystallography.

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收藏

页码：132 / 136

页数：5

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