Antimicrobial Resistance on Farms: A Review Including Biosecurity and the Potential Role of Disinfectants in Resistance Selection

被引:106
作者
Davies, Robert [1 ]
Wales, Andrew [2 ]
机构
[1] Anim & Plant Hlth Agcy APHA Weybridge, Bacteriol & Food Safety Dept, Woodham Lane, Addlestone KT15 3NB, Surrey, England
[2] Univ Surrey, Fac Hlth & Med Sci, Sch Vet Med, Pathol & Infect Dis Dept, Vet Sch Main Bldg,Daphne Jackson Rd, Guildford GU2 7AL, Surrey, England
关键词
antimicrobial; biosecurity; hygiene; livestock; resistance; QUATERNARY AMMONIUM-COMPOUNDS; SPECTRUM BETA-LACTAMASE; FOOD-PRODUCING ANIMALS; THERMOPHILIC CAMPYLOBACTER SPP; STAPHYLOCOCCUS-AUREUS ST398; LEVEL RISK-FACTORS; ESCHERICHIA-COLI; ANTIBIOTIC-RESISTANCE; SALMONELLA-ENTERICA; FLUOROQUINOLONE RESISTANCE;
D O I
10.1111/1541-4337.12438
中图分类号
TS2 [食品工业];
学科分类号
0832 ;
摘要
Resistance to therapeutic antimicrobial agents is recognized as a growing problem for both human and veterinary medicine, and the need to address the issue in both of these linked domains is a current priority in public policy. Efforts to limit antimicrobial resistance (AMR) on farms have so far focused on control of the supply and use of antimicrobial drugs, plus husbandry measures to reduce infectious disease. In the United Kingdom and some other countries, substantial progress has been made recently against targets on agricultural antimicrobial drug use. However, evidence suggests that resistant pathogenic and commensal bacteria can persist and spread within and between premises despite declining or zero antimicrobial drug use. Reasons for this are likely complex and varied but may include: bacterial adaptations to ameliorate fitness costs associated with maintenance and replication of resistance genes and associated proteins, horizontal transmission of genetic resistance determinants between bacteria, physical transfer of bacteria via movement (of animals, workers, and equipment), ineffective cleaning and disinfection, and co-selection of resistance to certain drugs by use of other antimicrobials, heavy metals, or biocides. Areas of particular concern for public health include extended-spectrum cephalosporinases and fluoroquinolone resistance among Enterobacteriaceae, livestock-associated methicillin-resistant Staphylococcus aureus, and the emergence of transmissible colistin resistance. Aspects of biosecurity have repeatedly been identified as risk factors for the presence of AMR on farm premises, but there are large gaps in our understanding of the most important risk factors and the most effective interventions. The present review aims to summarize the present state of knowledge in this area, from a European perspective.
引用
收藏
页码:753 / 774
页数:22
相关论文
共 213 条
[31]   Adaptive resistance to biocides in Salmonella enterica and Escherichia coli O157 and cross-resistance to antimicrobial agents [J].
Braoudaki, M ;
Hilton, AC .
JOURNAL OF CLINICAL MICROBIOLOGY, 2004, 42 (01) :73-78
[32]   Resistance of bacterial biofilms to disinfectants: a review [J].
Bridier, A. ;
Briandet, R. ;
Thomas, V. ;
Dubois-Brissonnet, F. .
BIOFOULING, 2011, 27 (09) :1017-1032
[33]   Biofilms of a Bacillus subtilis Hospital Isolate Protect Staphylococcus aureus from Biocide Action [J].
Bridier, Arnaud ;
Sanchez-Vizuete, Maria del Pilar ;
Le Coq, Dominique ;
Aymerich, Stephane ;
Meylheuc, Thierry ;
Maillard, Jean-Yves ;
Thomas, Vincent ;
Dubois-Brissonnet, Florence ;
Briandet, Romain .
PLOS ONE, 2012, 7 (09)
[34]   Efflux pump induction by quaternary ammonium compounds and fluoroquinolone resistance in bacteria [J].
Buffet-Bataillon, Sylvie ;
Tattevin, Pierre ;
Maillard, Jean-Yves ;
Bonnaure-Mallet, Martine ;
Jolivet-Gougeon, Anne .
FUTURE MICROBIOLOGY, 2016, 11 (01) :81-92
[35]   Emergence of resistance to antibacterial agents: the role of quaternary ammonium compounds-a critical review [J].
Buffet-Bataillon, Sylvie ;
Tattevin, Pierre ;
Bonnaure-Mallet, Martine ;
Jolivet-Gougeon, Anne .
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS, 2012, 39 (05) :381-389
[36]   The impact of triclosan on the spread of antibiotic resistance in the environment [J].
Carey, Daniel E. ;
McNamara, Patrick J. .
FRONTIERS IN MICROBIOLOGY, 2015, 5
[37]   Mechanisms of antimicrobial resistant Salmonella enterica transmission associated with starling-livestock interactions [J].
Carlson, James C. ;
Hyatt, Doreene R. ;
Ellis, Jeremy W. ;
Pipkin, David R. ;
Mangan, Anna M. ;
Russell, Michael ;
Bolte, Denise S. ;
Engeman, Richard M. ;
DeLiberto, Thomas J. ;
Linz, George M. .
VETERINARY MICROBIOLOGY, 2015, 179 (1-2) :60-68
[38]   Veterinary Expert Opinion on Potential Drivers and Opportunities for Changing Antimicrobial Usage Practices in Livestock in Denmark, Portugal, and Switzerland [J].
Carmo, Luis P. ;
Nielsen, Liza R. ;
Alban, Lis ;
da Costa, Paulo M. ;
Schupbach-Regula, Gertraud ;
Magouras, Ioannis .
FRONTIERS IN VETERINARY SCIENCE, 2018, 5
[39]   A comparison of the efficacy of cleaning and disinfection methods in eliminating Salmonella spp. from commercial egg laying houses [J].
Carrique-Mas, Juan J. ;
Marin, Clara ;
Breslin, Mark ;
McLaren, Ian ;
Davies, Rob .
AVIAN PATHOLOGY, 2009, 38 (05) :419-424
[40]   Attributable deaths and disability-adjusted life-years caused by infections with antibiotic-resistant bacteria in the EU and the European Economic Area in 2015: a population-level modelling analysis [J].
Cassini, Alessandro ;
Hogberg, Liselotte Diaz ;
Plachouras, Diamantis ;
Quattrocchi, Annalisa ;
Hoxha, Ana ;
Simonsen, Gunnar Skov ;
Colomb-Cotinat, Melanie ;
Kretzschmar, Mirjam E. ;
Devleesschauwer, Brecht ;
Cecchini, Michele ;
Ouakrim, Driss Ait ;
Oliveira, Tiago Cravo ;
Struelens, Marc J. ;
Suetens, Carl ;
Monnet, Dominique L. ;
Strauss, Reinhild ;
Mertens, Karl ;
Struyf, Thomas ;
Catry, Boudewijn ;
Latour, Katrien ;
Ivanov, Ivan Nikolaev ;
Dobreva, Elina Georgieva ;
Tambic Andrasevic, Arjana ;
Soprek, Silvija ;
Budimir, Ana ;
Paphitou, Niki ;
Zemlickova, Helena ;
Olsen, Stefan Schytte ;
Sonksen, Ute Wolff ;
Martin, Pille ;
Ivanova, Marina ;
Lyytikainen, Outi ;
Jalava, Jari ;
Coignard, Bruno ;
Eckmanns, Tim ;
Abu Sin, Muna ;
Haller, Sebastian ;
Daikos, George L. ;
Gikas, Achilleas ;
Tsiodras, Sotirios ;
Kontopidou, Flora ;
Toth, Akos ;
Hajdu, Agnes ;
Guolaugsson, Olafur ;
Kristinsson, Karl G. ;
Murchan, Stephen ;
Burns, Karen ;
Dsstat, Patrizio Pezzotti ;
Gagliotti, Carlo ;
Dumpis, Uga .
LANCET INFECTIOUS DISEASES, 2019, 19 (01) :56-66