Vitamin B-12 and Cognition in Children

被引：84

作者：

Venkatramanan, Sudha ^{[1
]}

Armata, Hanna E. ^{[1
]}

Strupp, Barbara J. ^{[1
,2
]}

Finkelstein, Julia L. ^{[1
,3
]}

机构：

[1] Cornell Univ, Div Nutr Sci, Ithaca, NY 14853 USA

[2] Cornell Univ, Dept Psychol, Ithaca, NY 14853 USA

[3] St Johns Res Inst, Bangalore, Karnataka, India

来源：

ADVANCES IN NUTRITION | 2016年 / 7卷 / 05期

关键词：

vitamin B-12; cobalamin; child; brain; cognition; ONE-CARBON METABOLISM; BRAIN-DEVELOPMENT; B-VITAMINS; COBALAMIN DEFICIENCY; SCHOOL-CHILDREN; INDIAN CHILDREN; FOLATE; HOMOCYSTEINE; NUTRITION; PREGNANCY;

D O I：

10.3945/an.115.012021

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

Vitamin B-12 is essential for brain development, neural myelination, and cognitive function. Inadequate vitamin B-12 status during pregnancy and early childhood has been associated with adverse child health outcomes, including impaired cognitive development. However, the underlying mechanisms have not been elucidated. This review was conducted to examine the evidence that links vitamin B-12 and cognition in children. The search strategy resulted in 17 studies: 3 cross-sectional, 1 case-control, and 12 cohort studies, and 1 randomized trial. Cognitive processes assessed included attention, memory, and perception. Developmental outcomes, academic performance, and intelligence quotient were also considered. Despite the high prevalence of vitamin B-12 insufficiency and associated risk of adverse cognitive outcomes in children, to our knowledge, no studies to date have been conducted to examine the effects of vitamin B-12 supplementation on cognition in children. The role of vitamin B-12 in the etiology of child cognitive outcomes needs to be elucidated to inform public health interventions.

引用

页码：879 / 888

页数：10

共 68 条

[21] Vitamin B12 deficiency in the brain leads to DNA hypomethylation in the TCblR/CD320 knockout mouse [J].