Biofunctionalized nanoporous gold for electrochemical biosensors

被引：57

作者：

Chen, L. Y. ^{[1
]}

Fujita, T. ^{[1
,2
]}

Chen, M. W. ^{[1
,3
,4
]}

机构：

[1] Tohoku Univ, Adv Inst Mat Res, World Premier Int WPI Res Ctr, Sendai, Miyagi 9808577, Japan

[2] PRESTO, JST, Kawaguchi, Saitama 3320012, Japan

[3] Shanghai Jiao Tong Univ, Sch Mat Sci & Engn, Shanghai 200030, Peoples R China

[4] Shanghai Jiao Tong Univ, State Key Lab Met Matrix Composites, Shanghai 200030, Peoples R China

来源：

ELECTROCHIMICA ACTA | 2012年 / 67卷

关键词：

Nanoporous gold; Glucose; Enzyme; Thiol; Biosensing; GLUCOSE SENSORS; ENZYME; NANOPARTICLES; ELECTRODE; FILM; ELECTROCATALYSIS; DEHYDROGENASE; SENSITIVITY; OXIDASE;

D O I：

10.1016/j.electacta.2011.12.132

中图分类号：

O646 [电化学、电解、磁化学];

学科分类号：

081704 ;

摘要：

We report an enzyme-modified nanoporous gold (NPG) biosensor with excellent sensitivity and selectivity towards the detection of glucose in the physiological environment containing common interferents. The internal surface of biocompatible NPG films is functionalized with glucose oxidase using thiols as linking molecules. The three-dimensional porous metal/organic hybrid electrode exhibits effective enzyme immobilization and peroxide detection on gold ligaments for amperometric glucose sensing. This study has important implications in developing NPG based metal/organic electrodes for electrochemical sensors with high selectivity and sensitivity. (C) 2012 Elsevier Ltd. All rights reserved.

引用

页码：1 / 5

页数：5

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