The makings of maleness: towards an integrated view of male sexual development

被引：140
作者：
Wilhelm, Dagmar
Koopman, Peter [1 ]
机构：
[1] Univ Queensland, Div Mol Genet & Dev, Inst Mol Biosci, Brisbane, Qld 4072, Australia
[2] Univ Queensland, ARC Ctr Excellence Biotechnol & Dev, Inst Mol Biosci, Brisbane, Qld 4072, Australia
来源：
NATURE REVIEWS GENETICS | 2006年 / 7卷 / 08期
基金：
英国医学研究理事会; 美国国家卫生研究院; 澳大利亚研究理事会;
关键词：
D O I：
10.1038/nrg1903
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
As the mammalian embryo develops, it must engage one of the two distinct programmes of gene activity, morphogenesis and organogenesis that characterize males and females. In males, sexual development hinges on testis determination and differentiation, but also involves many coordinated transcriptional, signalling and endocrine networks that underpin the masculinization of other organs and tissues, including the brain. Here we bring together current knowledge about these networks, identify gaps in the overall picture, and highlight the known defects that lead to disorders of male sexual development.
引用
收藏
页码：620 / 631
页数：12
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