Asymmetric amplification in the catalytic enantioselective 1,2-addition of Grignard reagents to enones

被引：23

作者：

Caprioli, Francesca ^{[1
]}

Madduri, Ashoka V. R. ^{[1
]}

Minnaard, Adriaan J. ^{[1
]}

Harutyunyan, Syuzanna R. ^{[1
]}

机构：

[1] Univ Groningen, Stratingh Inst Chem, NL-9747 AG Groningen, Netherlands

来源：

CHEMICAL COMMUNICATIONS | 2013年 / 49卷 / 48期

关键词：

CARBONYL-COMPOUNDS; TERTIARY ALCOHOLS; KETONES; ALDEHYDES; MECHANISM;

D O I：

10.1039/c3cc41892h

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Large asymmetric amplification originating from solubility differences between the enantiopure and the racemic catalyst is observed in the addition of Grignard reagents to enones. This behaviour is not reaction or catalyst specific and is observed for metal complexes of a variety of chiral diphosphine ligands, extensively used in asymmetric catalysis.

引用

页码：5450 / 5452

页数：3

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