A Chemical Probe for Lysine Malonylation

被引：67

作者：

Bao, Xiucong ^{[1
]}

Zhao, Qian ^{[1
]}

Yang, Tangpo ^{[1
]}

Fung, Yi Man Eva ^{[1
]}

Li, Xiang David ^{[1
]}

机构：

[1] Univ Hong Kong, Dept Chem, Hong Kong, Hong Kong, Peoples R China

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2013年 / 52卷 / 18期

关键词：

click chemistry; lysine malonylation; metabolic labeling; posttranslational modifications; protein modifications; FLUORESCENT DETECTION; ACYLATION; REPORTERS; SIRT5;

D O I：

10.1002/anie.201300252

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Tag! You′re it! MalAM-yne is a chemical reporter for malonylation of lysines within proteins (see scheme), a newly identified posttranslational modification. MalAM-yne is cell-permeable and metabolically incorporated into proteins in living cells. Subsequent bioorthogonal tag conjugation allows the fluorescent visualization of cellular malonylation and profiling of malonylated proteins. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：4883 / 4886

页数：4

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