Controlled degradation of polylactic acid grafting N-vinyl pyrrolidone induced by gamma ray radiation

被引：21

作者：

Peng, Chaorong ^{[1
]}

Chen, Hao ^{[1
]}

Wang, Jingxia ^{[1
]}

Chen, Zhuping ^{[1
]}

Ni, Maojun ^{[1
]}

Chen, Yuheng ^{[1
]}

Zhang, Jing ^{[1
]}

Yuan, Tun ^{[2
]}

机构：

[1] Sichuan Inst Atom Energy, Radiat Chem Dept, Chengdu 610101, Peoples R China

[2] Sichuan Univ, Engn Res Ctr Biomat, Chengdu 610064, Peoples R China

来源：

JOURNAL OF APPLIED POLYMER SCIENCE | 2013年 / 130卷 / 01期

关键词：

biodegradable; biocompatibility; grafting; irradiation; degradation; IN-VITRO DEGRADATION; HYDROLYTIC DEGRADATION; THERMAL-DEGRADATION; POLY(L-LACTIC ACID); SURFACE; FABRICATION; COPOLYMERS; MEMBRANES; POLYMERS;

D O I：

10.1002/app.39243

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

Polylactic acid (PLA) films were surface modified by gamma ray irradiation-induced grafting of N-vinyl pyrrolidone (NVP). The in vitro degradation behavior of polylactic acid grafting N-vinyl pyrrolidone (PLA-g-PVP) copolymer was analyzed in terms of weight loss, molecular weight, and thermal properties. Grafting NVP significantly accelerated the degradation of PLA. The mass losses of the copolymers, which were less than that of pure PLA at the beginning of the degradation period, sharply accelerated with increasing degradation time. Moreover, the crystallization temperature decreased with increasing degradation time in the same graft ratio, and the degree of crystallinity increased. Cytotoxicity experiments and animal experiments in vivo were carried out to evaluate the biocompatibility of PLA-g-PVP copolymer. Varying graft ratios of PVP could control the degradation rate of copolymers, and thus broadening the applications of this material, such as in tissue engineering scaffolds, drug delivery, and prevention of postsurgical adhesion. (c) 2013 Wiley Periodicals, Inc. J. Appl. Polym. Sci., 2013

引用

页码：704 / 709

页数：6

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