Controlled degradation of polylactic acid grafting N-vinyl pyrrolidone induced by gamma ray radiation

被引：21

作者：

Peng, Chaorong ^{[1
]}

Chen, Hao ^{[1
]}

Wang, Jingxia ^{[1
]}

Chen, Zhuping ^{[1
]}

Ni, Maojun ^{[1
]}

Chen, Yuheng ^{[1
]}

Zhang, Jing ^{[1
]}

Yuan, Tun ^{[2
]}

机构：

[1] Sichuan Inst Atom Energy, Radiat Chem Dept, Chengdu 610101, Peoples R China

[2] Sichuan Univ, Engn Res Ctr Biomat, Chengdu 610064, Peoples R China

来源：

JOURNAL OF APPLIED POLYMER SCIENCE | 2013年 / 130卷 / 01期

关键词：

biodegradable; biocompatibility; grafting; irradiation; degradation; IN-VITRO DEGRADATION; HYDROLYTIC DEGRADATION; THERMAL-DEGRADATION; POLY(L-LACTIC ACID); SURFACE; FABRICATION; COPOLYMERS; MEMBRANES; POLYMERS;

D O I：

10.1002/app.39243

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

Polylactic acid (PLA) films were surface modified by gamma ray irradiation-induced grafting of N-vinyl pyrrolidone (NVP). The in vitro degradation behavior of polylactic acid grafting N-vinyl pyrrolidone (PLA-g-PVP) copolymer was analyzed in terms of weight loss, molecular weight, and thermal properties. Grafting NVP significantly accelerated the degradation of PLA. The mass losses of the copolymers, which were less than that of pure PLA at the beginning of the degradation period, sharply accelerated with increasing degradation time. Moreover, the crystallization temperature decreased with increasing degradation time in the same graft ratio, and the degree of crystallinity increased. Cytotoxicity experiments and animal experiments in vivo were carried out to evaluate the biocompatibility of PLA-g-PVP copolymer. Varying graft ratios of PVP could control the degradation rate of copolymers, and thus broadening the applications of this material, such as in tissue engineering scaffolds, drug delivery, and prevention of postsurgical adhesion. (c) 2013 Wiley Periodicals, Inc. J. Appl. Polym. Sci., 2013

引用

页码：704 / 709

页数：6

共 29 条

[1] Use of radiation in biomaterials science [J].

Benson, RS .

NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION B-BEAM INTERACTIONS WITH MATERIALS AND ATOMS, 2002, 191 :752-757

[2] Thermal degradation of polyvinylpyrrolidone on the surface of pyrogenic silica [J].

Bogatyrev, VM ;

Borisenko, NV ;

Pokrovskii, VA .

RUSSIAN JOURNAL OF APPLIED CHEMISTRY, 2001, 74 (05) :839-844

[3] Polylactic acid/cellulose whisker nanocomposites modified by polyvinyl alcohol [J].

Bondeson, Daniel ;

Oksman, Kristiina .

COMPOSITES PART A-APPLIED SCIENCE AND MANUFACTURING, 2007, 38 (12) :2486-2492

[4] Synthesis and in vitro degradation of poly(N-vinyl-2-pyrrolidone)-based graft copolymers for biomedical applications [J].

Brunius, CF ;

Edlund, U ;

Albertsson, AC .

JOURNAL OF POLYMER SCIENCE PART A-POLYMER CHEMISTRY, 2002, 40 (21) :3652-3661

[5]

Burg KJL, 1997, J BIOMAT SCI-POLYM E, V9, P15

[6] Preparation and Characterization of poly(L-lactide) Membranes Prepared by γ-Radiation-Induced Grafting of N-Vinyl Pyrrolidone [J].

Chen, Hao ;

Peng, Chaorong ;

Yao, Yongyi ;

Wang, Jingxia ;

Chen, Zhuping ;

Yang, Zhirong ;

Xia, Lijun ;

Liu, Siyang .

JOURNAL OF APPLIED POLYMER SCIENCE, 2009, 114 (05) :3152-3157

[7] Gas plasmas and plasma modified materials in medicine [J].

Cheruthazhekatt, Sadiqali ;

Cernak, Mirko ;

Slavicek, Pavel ;

Havel, Josef .

JOURNAL OF APPLIED BIOMEDICINE, 2010, 8 (02) :55-66

[8] INVESTIGATION OF STRUCTURE OF SOLUTION GROWN CRYSTALS OF LACTIDE COPOLYMERS BY MEANS OF CHEMICAL-REACTIONS [J].

FISCHER, EW ;

STERZEL, HJ ;

WEGNER, G .

KOLLOID-ZEITSCHRIFT AND ZEITSCHRIFT FUR POLYMERE, 1973, 251 (11) :980-990

[9] Characterization of poly(vinyl pyrrolidone) modified polyaniline prepared in stable aqueous medium [J].

Ghosh, P ;

Siddhanta, SK ;

Chakrabarti, A .

EUROPEAN POLYMER JOURNAL, 1999, 35 (04) :699-710

[10] Bone regeneration in segmental defects with resorbable polymeric membranes:: IV.: Does the polymer chemical composition affect the healing process? [J].

Gogolewski, S ;

Pineda, L ;

Büsing, CM .

BIOMATERIALS, 2000, 21 (24) :2513-2520

← 1 2 3 →