Synthesis of Electron-Deficient Chiral Biphenols and Their Applications in Catalytic Asymmetric Reactions

被引：5

作者：

Yasumoto, Kento ^{[1
]}

Kano, Taichi ^{[1
]}

Maruoka, Keiji ^{[1
,2
,3
]}

机构：

[1] Kyoto Univ, Grad Sch Sci, Dept Chem, Kyoto 6068502, Japan

[2] Kyoto Univ, Grad Sch Pharmaceut Sci, Kyoto 6068501, Japan

[3] Guangdong Univ Technol, Sch Chem Engn & Light Ind, Guangzhou 510006, Peoples R China

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2020年 / 85卷 / 15期

关键词：

TRIMETHOXYSILYL ENOL ETHERS; MANNICH-TYPE REACTIONS; DIELS-ALDER REACTIONS; IN-SITU GENERATION; N-BOC-IMINES; BRONSTED ACID; ENANTIOSELECTIVE ADDITION; ALDOL REACTION; BINOL; DERIVATIVES;

D O I：

10.1021/acs.joc.0c01116

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The axially chiral biphenols are known as a broadly applicable chiral source. However, only a few electron-deficient ones have been reported to date. In the present study, chiral biphenols having several electron-withdrawing groups have been designed, and a facile synthetic route from readily available reagents has been developed. Newly synthesized chiral electron-deficient biphenols and biphenol-derived chiral Bronsted acids functioned as effective catalysts for several catalytic asymmetric reactions.

引用

页码：10232 / 10239

页数：8

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