Combination of structural and vascular optical coherence tomography for differentiating oral lesions of mice in different carcinogenesis stages

被引：24

作者：

Chen, Ping-Hisen ^{[1
,2
,3
]}

Wu, Chien-Hsien ^{[3
]}

Chen, Yi-Fen ^{[4
]}

Yeh, Yi-Chen ^{[5
]}

Lin, Bo-Han ^{[3
]}

Chang, Kuo-Wei ^{[4
,6
,7
]}

Lai, Pei-Yu ^{[3
]}

Hou, Ming-Chih ^{[1
,2
,8
]}

Lu, Ching-Liang ^{[1
,2
]}

Kuo, Wen-Chuan ^{[3
]}

机构：

[1] Taipei Vet Gen Hosp, Endoscopy Ctr Diag & Treatment, Taipei 112, Taiwan

[2] Natl Yang Ming Univ Sch, Sch Med, Fac Med, Taipei 112, Taiwan

[3] Natl Yang Ming Univ, Inst Biophoton, Taipei 112, Taiwan

[4] Natl Yang Ming Univ, Inst Oral Biol, Taipei 112, Taiwan

[5] Taipei Vet Gen Hosp, Dept Pathol & Lab Med, Taipei 112, Taiwan

[6] Natl Yang Ming Univ, Dept Dent, Taipei 112, Taiwan

[7] Taipei Vet Gen Hosp, Dept Stomatol, Taipei 112, Taiwan

[8] Taipei Vet Gen Hosp, Dept Med, Taipei 112, Taiwan

来源：

BIOMEDICAL OPTICS EXPRESS | 2018年 / 9卷 / 04期

关键词：

IN-VIVO; CANCER; DIAGNOSIS; MICROVASCULATURE; MAGNIFICATION; CARCINOMA; WORKERS; CAVITY; HEAD; SKIN;

D O I：

10.1364/BOE.9.001461

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Differentiating between early malignancy and benign lesions in oral cavities is difficult using current optical tools. As has been shown in previous studies, microvascular changes in squamous epithelium can be regarded as a key marker for diagnosis. We propose the combination of structural and vascular optical coherence tomography (OCT) imaging for the investigation of disease related changes. Progressive thickness changes of epithelium and the destruction of underlying lamina propria was observed during cancer development in a 4nitroquinoline-1-oxide (4NQO) mouse model. At the same time, microvascular changes in hyperplasia, dysplasia, carcinoma in situ and advanced cancer were observed. Findings from OCT imaging were compared with histology. (c) 2018 Optical Society of America under the terms of the OSA Open Access Publishing Agreement

引用

页码：1461 / 1476

页数：16

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