Mitochondria in Ovarian Aging and Reproductive Longevity

被引：142

作者：

Chiang, Jasmine L. ^{[1
]}

Shukla, Pallavi ^{[2
,3
]}

Pagidas, Kelly ^{[4
]}

Ahmed, Noha S. ^{[2
,5
]}

Karri, Srinivasu ^{[2
]}

Gunn, Deidre D. ^{[1
]}

Hurd, William W. ^{[1
]}

Singh, Keshav K. ^{[2
,6
]}

机构：

[1] Univ Alabama Birmingham, Div Reprod Endocrinol & Infertil, 1700 6th Ave South, Birmingham, AL 35233 USA

[2] Univ Alabama Birmingham, Dept Genet, Kaul Genet Bldg Room 630,720 20th St South, Birmingham, AL 35294 USA

[3] Natl Inst Res Reprod Hlth NIRRH, Dept Mol Endocrinol, Jehangir Merwanji St, Mumbai 400012, Maharashtra, India

[4] TCM Univ, Dept Reprod Med, 9 Jason Dr, Lincoln, RI 02865 USA

[5] Zagazig Univ, Dept Dermatol, 44519 Shaibet Nakareyah,Zagazig 2, Ash Sharqia Governorate, Egypt

[6] Univ Alabama Birmingham, UAB Dept Genet, Ctr Womens Reprod Hlth, Kaul Genet Bldg,Room 620,720 20th St South, Birmingham, AL 35294 USA

来源：

AGEING RESEARCH REVIEWS | 2020年 / 63卷

关键词：

Mitochondrial dysfunction; Ovarian aging; Mitochondrial DNA; Reproductive longevity; Mitochondrial therapies; Infertility; INTRACYTOPLASMIC SPERM INJECTION; DNA COPY NUMBER; OXIDATIVE STRESS; HUMAN OOCYTES; DEOXYRIBONUCLEIC-ACID; TRANSCRIPTION FACTOR; SPINDLE TRANSFER; WOMEN; FERTILITY; BIRTH;

D O I：

10.1016/j.arr.2020.101168

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Mitochondrial dysfunction is one of the hallmarks of aging. Consistently mitochondrial DNA (mtDNA) copy number and function decline with age in various tissues. There is increasing evidence to support that mitochondrial dysfunction drives ovarian aging. A decreased mtDNA copy number is also reported during ovarian aging. However, the mitochondrial mechanisms contributing to ovarian aging and infertility are not fully understood. Additionally, investigations into mitochondrial therapies to rejuvenate oocyte quality, select viable embryos and improve mitochondrial function may help enhance fertility or extend reproductive longevity in the future. These therapies include the use of mitochondrial replacement techniques, quantification of mtDNA copy number, and various pharmacologic and lifestyle measures. This review aims to describe the key evidence and current knowledge of the role of mitochondria in ovarian aging and identify the emerging potential options for therapy to extend reproductive longevity and improve fertility.

引用

页数：12

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