Mitochondria in Ovarian Aging and Reproductive Longevity

被引：142
作者：
Chiang, Jasmine L. [1 ]
Shukla, Pallavi [2 ,3 ]
Pagidas, Kelly [4 ]
Ahmed, Noha S. [2 ,5 ]
Karri, Srinivasu [2 ]
Gunn, Deidre D. [1 ]
Hurd, William W. [1 ]
Singh, Keshav K. [2 ,6 ]
机构：
[1] Univ Alabama Birmingham, Div Reprod Endocrinol & Infertil, 1700 6th Ave South, Birmingham, AL 35233 USA
[2] Univ Alabama Birmingham, Dept Genet, Kaul Genet Bldg Room 630,720 20th St South, Birmingham, AL 35294 USA
[3] Natl Inst Res Reprod Hlth NIRRH, Dept Mol Endocrinol, Jehangir Merwanji St, Mumbai 400012, Maharashtra, India
[4] TCM Univ, Dept Reprod Med, 9 Jason Dr, Lincoln, RI 02865 USA
[5] Zagazig Univ, Dept Dermatol, 44519 Shaibet Nakareyah,Zagazig 2, Ash Sharqia Governorate, Egypt
[6] Univ Alabama Birmingham, UAB Dept Genet, Ctr Womens Reprod Hlth, Kaul Genet Bldg,Room 620,720 20th St South, Birmingham, AL 35294 USA
来源：
AGEING RESEARCH REVIEWS | 2020年 / 63卷
关键词：
Mitochondrial dysfunction; Ovarian aging; Mitochondrial DNA; Reproductive longevity; Mitochondrial therapies; Infertility; INTRACYTOPLASMIC SPERM INJECTION; DNA COPY NUMBER; OXIDATIVE STRESS; HUMAN OOCYTES; DEOXYRIBONUCLEIC-ACID; TRANSCRIPTION FACTOR; SPINDLE TRANSFER; WOMEN; FERTILITY; BIRTH;
D O I：
10.1016/j.arr.2020.101168
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Mitochondrial dysfunction is one of the hallmarks of aging. Consistently mitochondrial DNA (mtDNA) copy number and function decline with age in various tissues. There is increasing evidence to support that mitochondrial dysfunction drives ovarian aging. A decreased mtDNA copy number is also reported during ovarian aging. However, the mitochondrial mechanisms contributing to ovarian aging and infertility are not fully understood. Additionally, investigations into mitochondrial therapies to rejuvenate oocyte quality, select viable embryos and improve mitochondrial function may help enhance fertility or extend reproductive longevity in the future. These therapies include the use of mitochondrial replacement techniques, quantification of mtDNA copy number, and various pharmacologic and lifestyle measures. This review aims to describe the key evidence and current knowledge of the role of mitochondria in ovarian aging and identify the emerging potential options for therapy to extend reproductive longevity and improve fertility.
引用
收藏
页数：12
相关论文
共 123 条
[1]   First birth following spindle transfer for mitochondrial replacement therapy: hope and trepidation [J].
Alikani, Mina ;
Fauser, Bart C. J. ;
Garcia-Valesco, Juan Antonio ;
Simpson, Joe Leigh ;
Johnson, Martin H. .
REPRODUCTIVE BIOMEDICINE ONLINE, 2017, 34 (04) :333-336
[2]   Epigenetics in Turner syndrome [J].
Alvarez-Nava, Francisco ;
Lanes, Roberto .
CLINICAL EPIGENETICS, 2018, 10
[3]   Mitochondrial Dynamics - Mitochondrial Fission and Fusion in Human Diseases [J].
Archer, Stephen L. .
NEW ENGLAND JOURNAL OF MEDICINE, 2013, 369 (23) :2236-2251
[4]   Oxidative Stress in Granulosa-Lutein Cells From In Vitro Fertilization Patients [J].
Avila, Julio ;
Gonzalez-Fernandez, Rebeca ;
Rotoli, Deborah ;
Hernandez, Jairo ;
Palumbo, Angela .
REPRODUCTIVE SCIENCES, 2016, 23 (12) :1656-1661
[5]  
Barritt J A, 2000, Reprod Biomed Online, V1, P96
[6]   Mitochondrial DNA rearrangements in human oocytes and embryos [J].
Barritt, JA ;
Brenner, CA ;
Cohen, J ;
Matt, DW .
MOLECULAR HUMAN REPRODUCTION, 1999, 5 (10) :927-933
[7]   Effect of follicular fluid oxidative stress parameters on intracytoplasmic sperm injection outcome [J].
Bedaiwy, Mohamed A. ;
El-Nashar, Sherif A. ;
Goldberg, Jeffrey M. ;
Sharma, Rakesh ;
Mascha, Edward J. ;
Arrigain, Susana ;
Agarwal, Ashok ;
Falcone, Tommaso .
GYNECOLOGICAL ENDOCRINOLOGY, 2012, 28 (01) :51-55
[8]   Coenzyme Q10 restores oocyte mitochondrial function and fertility during reproductive aging [J].
Ben-Meir, Assaf ;
Burstein, Eliezer ;
Borrego-Alvarez, Aluet ;
Chong, Jasmine ;
Wong, Ellen ;
Yavorska, Tetyana ;
Naranian, Taline ;
Chi, Maggie ;
Wang, Ying ;
Bentov, Yaakov ;
Alexis, Jennifer ;
Meriano, James ;
Sung, Hoon-Ki ;
Gasser, David L. ;
Moley, Kelle H. ;
Hekimi, Siegfried ;
Casper, Robert F. ;
Jurisicova, Andrea .
AGING CELL, 2015, 14 (05) :887-895
[9]   Coenzyme Q10 Supplementation and Oocyte Aneuploidy in Women Undergoing IVF-ICSI Treatment [J].
Bentov, Yaakov ;
Hannam, Thomas ;
Jurisicova, Andrea ;
Esfandiari, Navid ;
Casper, Robert F. .
CLINICAL MEDICINE INSIGHTS-REPRODUCTIVE HEALTH, 2014, 8 :31-36
[10]   Oxidative Stress and Antioxidant Defense [J].
Birben, Esra ;
Sahiner, Umit Murat ;
Sackesen, Cansin ;
Erzurum, Serpil ;
Kalayci, Omer .
WORLD ALLERGY ORGANIZATION JOURNAL, 2012, 5 :9-19
12345678910